ArticleJournal of dental research2018
Rare and Common Variants Conferring Risk of Tooth Agenesis.
Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association between tooth agenesis and cancer: a systematic review.Journal of applied oral science : revista FOB · 2021Pooled it
- Genome-wide analysis of dental caries and periodontitis combining clinical and self-reported data.Nature communications · 2019Pooled it
- A Signaling-Threshold Framework for Human Tooth Agenesis: Integrating Molecular Genetics with Developmental Field Theory.International journal of molecular sciences · 2026Review
- Article
- Dissecting the Genetic Contribution of Tooth Agenesis.International journal of molecular sciences · 2025Review
- GJA8-associated developmental eye disorders: a new multicentre study highlights mutational hotspots and genotype-phenotype correlations.European journal of human genetics : EJHG · 2025Article
- Main genetic entities associated with tooth agenesis.Clinical oral investigations · 2024Review
- The Importance of Basic Sciences in Dental Education.Dentistry journal · 2024Article
- Article
- Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement.PLoS genetics · 2024Article
- CACNA1S mutation-associated dental anomalies: A calcium channelopathy.Oral diseases · 2024Article
- Bioinformatics for Dentistry: A secondary database for the genetics of tooth development.PloS one · 2024Article
- Count Me in, Count Me out: Regulation of the Tooth Number via Three Directional Developmental Patterns.International journal of molecular sciences · 2023Review
- Wnt signaling: Essential roles in osteoblast differentiation, bone metabolism and therapeutic implications for bone and skeletal disorders.Genes & diseases · 2023Review
- Oral and craniofacial research in the Generation R study: an executive summary.Clinical oral investigations · 2023Article
- Advances in tooth agenesis and tooth regeneration.Regenerative therapy · 2023Review
- Identification of potential key variants in mandibular premolar hypodontia through whole-exome sequencing.Frontiers in genetics · 2023Article
- The EDA/EDAR/NF-κB pathway in non-syndromic tooth agenesis: A genetic perspective.Frontiers in genetics · 2023Review
- Rethinking the Genetic Etiology of Nonsyndromic Tooth Agenesis.Current osteoporosis reports · 2022Review
- Article
Corrections and comments
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Authors and funding
36 authors.
Funding
Abstract
We present association results from a large genome-wide association study of tooth agenesis (TA) as well as selective TA, including 1,944 subjects with congenitally missing teeth, excluding third molars, and 338,554 controls, all of European ancestry. We also tested the association of previously identified risk variants, for timing of tooth eruption and orofacial clefts, with TA. We report associations between TA and 9 novel risk variants. Five of these variants associate with selective TA, including a variant conferring risk of orofacial clefts. These results contribute to a deeper understanding of the genetic architecture of tooth development and disease. The few variants previously associated with TA were uncovered through candidate gene studies guided by mouse knockouts. Knowing the etiology and clinical features of TA is important for planning oral rehabilitation that often involves an interdisciplinary approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.