ArticleJournal of visualized experiments : JoVE2017
An In Vivo Duo-color Method for Imaging Vascular Dynamics Following Contusive Spinal Cord Injury.
Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Boron neutron capture therapy prolongs survival in a rat model of multifocal brain metastases.Journal of neuro-oncology · 2026Article
- Advanced technologies of artery-on-a-chip: a review of construction strategies and disease models.Angiogenesis · 2026Review
- The Distinct Characteristics of Somatostatin Neurons in the Human Brain.Molecular neurobiology · 2022Article
- Review
- Insights Into Leukocyte Trafficking in Inflammatory Arthritis - Imaging the Joint.Frontiers in cell and developmental biology · 2021Review
- Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains.Scientific reports · 2020Article
- Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- Surgical preparations, labeling strategies, and optical techniques for cell-resolved, in vivo imaging in the mouse spinal cord.Experimental neurology · 2019Review
- NEPJournal of nanobiotechnology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Spinal cord injury (SCI) causes significant vascular disruption at the site of injury. Vascular pathology occurs immediately after SCI and continues throughout the acute injury phase. In fact, endothelial cells appear to be the first to die after a contusive SCI. The early vascular events, including increased permeability of the blood-spinal cord barrier (BSCB), induce vasogenic edema and contribute to detrimental secondary injury events caused by complex injury mechanisms. Targeting the vascular disruption, therefore, could be a key strategy to reduce secondary injury cascades that contribute to histological and functional impairments after SCI. Previous studies were mostly performed on postmortem samples and were unable to capture the dynamic changes of the vascular network. In this study, we have developed an in vivo duo-color two-photon imaging method to monitor acute vascular dynamic changes following contusive SCI. This approach allows detecting blood flow, vessel diameter, and other vascular pathologies at various sites of the same rat pre- and post-injury. Overall, this method provides an excellent venue for investigating vascular dynamics.
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Registered trials
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