Evidence map›Paper›PMID 29363939›Full record

ArticleACS chemical neuroscience2018

Bad Behavior: Improving Reproducibility in Behavior Testing.

Anne M Andrews, Xinyi Cheng, Stefanie C Altieri, Hongyan Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anne M AndrewsDepartments of Psychiatry & Biobehavioral Sciences and Chemistry & Biochemistry, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology , University of California , Los Angeles , California 90095 , United States.ORCID 0000-0002-1961-4833
Xinyi ChengDepartments of Psychiatry & Biobehavioral Sciences and Chemistry & Biochemistry, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology , University of California , Los Angeles , California 90095 , United States.
Stefanie C AltieriDepartments of Psychiatry & Biobehavioral Sciences and Chemistry & Biochemistry, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology , University of California , Los Angeles , California 90095 , United States.
Hongyan YangDepartments of Psychiatry & Biobehavioral Sciences and Chemistry & Biochemistry, Semel Institute for Neuroscience and Human Behavior, and Hatos Center for Neuropharmacology , University of California , Los Angeles , California 90095 , United States.

Funding

Prenatal stress and antidepressants effects on offspring brain developmentR01MH106806 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BONNIN, ALEXANDRE · 2016 to 2020
$2.1M
Postnatal Antidepressant Effects on Periadolescent SERT Function by VoltammetryR03MH086108 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDREWS, ANNE MILASINCIC · 2009 to 2010
$149k
NIMH NIH HHS R01 MH106806NIMH NIH HHS R03 MH086108
6 · The paper itself

Abstract

Systems neuroscience research is increasingly possible through the use of integrated molecular and circuit-level analyses. These studies depend on the use of animal models and, in many cases, molecular and circuit-level analyses. Associated with genetic, pharmacologic, epigenetic, and other types of environmental manipulations. We illustrate typical pitfalls resulting from poor validation of behavior tests. We describe experimental designs and enumerate controls needed to improve reproducibility in investigating and reporting of behavioral phenotypes.

Indexed as

Behavior, AnimalBehavior Rating ScaleReproducibility of ResultsAnimalsFeeding BehaviorFemaleMaleMaze LearningMice, TransgenicResearch DesignSerotonin Plasma Membrane Transport ProteinsValidation Studies as TopicSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mousebehavior testingmodel systemReproducibility

Identifiers

PMID29363939
PMCPMC6100770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.