ArticleAdvanced materials (Deerfield Beach, Fla.)2018
Oriented Nanofibrous Polymer Scaffolds Containing Protein-Loaded Porous Silicon Generated by Spray Nebulization.
Article in Advanced materials (Deerfield Beach, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Recent advances in theranostic nanomaterials for overcoming traumatic brain injury.Journal of nanobiotechnology · 2025Review
- Recent Advances of Macrostructural Porous Silicon for Biomedical Applications.ACS applied materials & interfaces · 2025Review
- Harnessing the Materials Chemistry of Mesoporous Silicon Nanoparticles to Prepare "Armor-Clad" Enzymes.Chemistry of materials : a publication of the American Chemical Society · 2023Article
- Wearable patches for transdermal drug delivery.Acta pharmaceutica Sinica. B · 2023Review
- Inorganic/organic combination: Inorganic particles/polymer composites for tissue engineering applications.Bioactive materials · 2023Article
- Nanomaterial payload delivery to central nervous system glia for neural protection and repair.Frontiers in cellular neuroscience · 2023Review
- Enteric Polymer-Coated Porous Silicon Nanoparticles for Site-Specific Oral Delivery of IgA Antibody.ACS biomaterials science & engineering · 2022Article
- Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury.Bioconjugate chemistry · 2022Article
- Nanofiber Carriers of Therapeutic Load: Current Trends.International journal of molecular sciences · 2022Review
- Recent advances in hybrid system of porous silicon nanoparticles and biocompatible polymers for biomedical applications.Biomedical engineering letters · 2021Review
- 3D Electrospun Synthetic Extracellular Matrix for Tissue Regeneration.Small science · 2021Article
- Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles.Molecular pharmaceutics · 2021Article
- Porous Silicon Nanoparticles Embedded in Poly(lactic-Advanced functional materials · 2020Article
- Biomaterial strategies for creatingCurrent opinion in biomedical engineering · 2020Article
- Oriented Neural Spheroid Formation and Differentiation of Neural Stem Cells Guided by Anisotropic Inverse Opals.Frontiers in bioengineering and biotechnology · 2020Article
- Vastly extended drug release from poly(pro-17β-estradiol) materials facilitates in vitro neurotrophism and neuroprotection.Nature communications · 2019Article
- Biomaterial Approaches to Modulate Reactive Astroglial Response.Cells, tissues, organs · 2018Review
- Enhance the biocompatibility and osseointegration of polyethylene terephthalate ligament by plasma spraying with hydroxyapatite in vitro and in vivo.International journal of nanomedicine · 2018Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Oriented composite nanofibers consisting of porous silicon nanoparticles (pSiNPs) embedded in a polycaprolactone or poly(lactide-co-glycolide) matrix are prepared by spray nebulization from chloroform solutions using an airbrush. The nanofibers can be oriented by an appropriate positioning of the airbrush nozzle, and they can direct growth of neurites from rat dorsal root ganglion neurons. When loaded with the model protein lysozyme, the pSiNPs allow the generation of nanofiber scaffolds that carry and deliver the protein under physiologic conditions (phosphate-buffered saline (PBS), at 37 °C) for up to 60 d, retaining 75% of the enzymatic activity over this time period. The mass loading of protein in the pSiNPs is 36%, and in the resulting polymer/pSiNP scaffolds it is 3.6%. The use of pSiNPs that display intrinsic photoluminescence (from the quantum-confined Si nanostructure) allows the polymer/pSiNP composites to be definitively identified and tracked by time-gated photoluminescence imaging. The remarkable ability of the pSiNPs to protect the protein payload from denaturation, both during processing and for the duration of the long-term aqueous release study, establishes a model for the generation of biodegradable nanofiber scaffolds that can load and deliver sensitive biologics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.