Evidence map›Paper›PMID 29363670›Full record

ArticleMucosal immunology2018

Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.

C Zhang, J T Jones, H S Chand, M G Wathelet, C M Evans, B Dickey, J Xiang, Y A Mebratu, Y Tesfaigzi

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

C ZhangCOPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
J T JonesCOPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
H S ChandCOPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
M G WatheletInfectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
C M EvansPulmonary Sciences and Critical Care Medicine, University of Colorado, Denver, Colorado, USA.
B DickeyDivision of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
J XiangDepartment of Biological and Chemical Sciences, Illinois Institute of Technology, Chicago, Illinois, USA.
Y A MebratuCOPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
Y TesfaigziCOPD Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA.
Lovelace Respiratory Research Institute · USIllinois Institute of Technology · USThe University of Texas MD Anderson Cancer Center · USUniversity of Colorado Denver · US

Funding

Resolution of Epithelial Cell Hyperplasia in AsthmaR01HL068111 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2003 to 2021
$10.9M
Role of Mucin in Lung Homeostasis and PathophysiologyR01HL080396 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Christopher M Evans · 2009 to 2026
$8.6M
Mechanisms of lung macrophage programming by MUC5B during health and diseaseR01HL130938 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI EVANS, CHRISTOPHER M · 2016 to 2025
$5.2M
Controlling the core airway mucin secretion machinery to prevent pathophysiologyR01HL129795 · NHLBI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DICKEY, BURTON F · 2015 to 2023
$3.8M
Resolution of Epithelial Cell HyperplasiaR01ES015482 · NIEHS · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2009 to 2013
$2.6M
Regulation of Mucous Cell Metaplasia in AsthmaR56HL068111 · NHLBI · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI TESFAIGZI, YOHANNES · 2007 to 2007
$500k
NHLBI NIH HHS R01 HL068111NHLBI NIH HHS R01 HL080396NHLBI NIH HHS R01 HL129795NHLBI NIH HHS R01 HL130938NHLBI NIH HHS R56 HL068111NIEHS NIH HHS R01 ES015482
6 · The paper itself

Abstract

IFN-γ is known as a pro-inflammatory cytokine, but can also block inflammation in certain chronic diseases although the underlying mechanisms are poorly understood. We found that IFN-γ rapidly induced Noxa expression and that extent of inflammation by repeated house dust mite exposure was enhanced in noxa

Indexed as

AnimalsAntigens, DermatophagoidesDisease Models, AnimalHSP27 Heat-Shock ProteinsHumansHypersensitivityInterferon-gammaMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNF-KappaB Inhibitor alphaPneumoniaProteolysisProto-Oncogene Proteins c-bcl-2PyroglyphidaeAntigens, DermatophagoidesHSP27 Heat-Shock ProteinsHspb2 protein, mouseInterferon-gammaNF-KappaB Inhibitor alphaPmaip1 protein, mouseProto-Oncogene Proteins c-bcl-2

Identifiers

PMID29363670
PMCPMC5976511
OpenAlexW2792775175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.