ArticleThe Journal of biological chemistry2018
The long non-coding RNA Gm10768 activates hepatic gluconeogenesis by sequestering microRNA-214 in mice.
Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Epigenetic regulation in a high-sugar environment (Review).International journal of molecular medicine · 2026Review
- A systematic review on type 3 diabetes: bridging the gap between metabolic dysfunction and Alzheimer's disease.Diabetology & metabolic syndrome · 2025Review
- The bidirectional regulatory network between ATF4 and lncRNAs in systemic diseases.Frontiers in oncology · 2025Review
- Review
- MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice.Biological research · 2024Article
- The role of long non-coding RNAs in carbohydrate and fat metabolism in the liver.Non-coding RNA research · 2023Review
- T2DB: A Web Database for Long Non-Coding RNA Genes in Type II Diabetes.Non-coding RNA · 2023Article
- Human milk-derived extracellular vesicles alleviate high fat diet-induced non-alcoholic fatty liver disease in mice.Molecular biology reports · 2023Article
- Recent advances of long non-coding RNAs in control of hepatic gluconeogenesis.Frontiers in endocrinology · 2023Review
- Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways.Annual review of nutrition · 2022Review
- Bicyclol Regulates Hepatic Gluconeogenesis in Rats with Type 2 Diabetes and Non-alcoholic Fatty Liver Disease by Inhibiting Inflammation.Frontiers in pharmacology · 2021Article
- Identifying potential functional lncRNAs in metabolic syndrome by constructing a lncRNA-miRNA-mRNA network.Journal of human genetics · 2020Article
- Integration of peripheral circadian clock and energy metabolism in metabolic tissues.Journal of molecular cell biology · 2020Review
- Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress.Frontiers in endocrinology · 2020Review
- Temporal expression and functional analysis of long non-coding RNAs in colorectal cancer initiation.Journal of cellular and molecular medicine · 2019Article
- Long noncoding RNAs in the metabolic control of inflammation and immune disorders.Cellular & molecular immunology · 2019Review
- ncRNA2MetS: a manually curated database for non-coding RNAs associated with metabolic syndrome.PeerJ · 2019Article
- The Role of Long Noncoding RNAs in Diabetic Alzheimer's Disease.Journal of clinical medicine · 2018Article
- The adaptor protein GIPC1 stabilizes the scavenger receptor SR-B1 and increases its cholesterol uptake.The Journal of biological chemistryArticle
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overactivated hepatic gluconeogenesis contributes to the pathogenesis of metabolic disorders, including type 2 diabetes. Precise control of hepatic gluconeogenesis is thus critical for maintaining whole-body metabolic homeostasis. Long non-coding RNAs (lncRNAs) have been shown to play key roles in diseases by regulating diverse biological processes, but the function of lncRNAs in maintaining normal physiology, particularly glucose homeostasis in the liver, remains largely unexplored. We identified a novel liver-enriched long non-coding RNA, Gm10768, and examined its expression patterns under pathophysiological conditions. We further adopted gain- and loss-of-function strategies to explore the effect of Gm10768 on hepatic glucose metabolism and the possible molecular mechanism involved. Our results showed that the expression of Gm10768 was significantly increased in the liver of fasted mice and was induced by gluconeogenic hormonal stimuli. Functionally, overexpression of Gm10768 activated hepatic gluconeogenesis in a cell-autonomous manner. In contrast, depletion of Gm10768 suppressed hepatic glucose production both
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