Evidence map›Paper›PMID 29363540›Full record

ArticleBlood2018

Remodeling of the malaria parasite and host human red cell by vesicle amplification that induces artemisinin resistance.

Souvik Bhattacharjee, Isabelle Coppens, Alassane Mbengue, Niraja Suresh, Mehdi Ghorbal, Zdenek Slouka, Innocent Safeukui, Hsin-Yao Tang, David W Speicher, Robert V Stahelin and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Vesicular mechanisms of drug resistance in apicomplexan parasites.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  9. Article
  10. Overexpression inFrontiers in cellular and infection microbiology · 2025
    Article
  11. Article
  12. Epidemiology, Detection and Treatment of Malaria.Tropical medicine and infectious disease · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Identification of anFrontiers in parasitology · 2023
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Souvik BhattacharjeeBoler-Parseghian Center for Rare and Neglected Diseases and.ORCID 0000-0002-3782-5677
Isabelle CoppensDepartment of Molecular Microbiology and Immunology, Malaria Research Institute, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Alassane MbengueBoler-Parseghian Center for Rare and Neglected Diseases and.
Niraja SureshBoler-Parseghian Center for Rare and Neglected Diseases and.
Mehdi GhorbalBoler-Parseghian Center for Rare and Neglected Diseases and.
Zdenek SloukaBoler-Parseghian Center for Rare and Neglected Diseases and.
Innocent SafeukuiBoler-Parseghian Center for Rare and Neglected Diseases and.
Hsin-Yao TangCenter for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, Wistar Proteomics and Metabolomics Facility, Wistar Institute, Philadelphia, PA.
David W SpeicherCenter for Systems and Computational Biology and Molecular and Cellular Oncogenesis Program, Wistar Proteomics and Metabolomics Facility, Wistar Institute, Philadelphia, PA.
Robert V StahelinBoler-Parseghian Center for Rare and Neglected Diseases and.
Narla MohandasRed Cell Physiology Laboratory, New York Blood Center, New York, NY.
Kasturi HaldarBoler-Parseghian Center for Rare and Neglected Diseases and.ORCID 0000-0001-5065-158X
University of Notre Dame · USThe Wistar Institute · USJohns Hopkins University · USNew York Blood Center · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Trafficking Signals in P. FalciparumR01HL069630 · NHLBI · UNIVERSITY OF NOTRE DAME · PI HALDAR, KASTURI · 2001 to 2017
$4.8M
Proteostatic Mechanisms of Resistance in MalariaR01HL130330 · NHLBI · UNIVERSITY OF NOTRE DAME · PI HALDAR, KASTURI · 2016 to 2019
$1.8M
NCI NIH HHS P30 CA010815NHLBI NIH HHS R01 HL069630NHLBI NIH HHS R01 HL130330
6 · The paper itself

Abstract

Artemisinin resistance threatens worldwide malaria control and elimination. Elevation of phosphatidylinositol-3-phosphate (PI3P) can induce resistance in blood stages of

Indexed as

Drug ResistanceEndoplasmic ReticulumPlasmodium falciparumProtozoan ProteinsUnfolded Protein ResponseArtemisininsErythrocytesHumansLactonesMutationProteomeProteostasisartemisinArtemisininserythrocyte membrane protein 1, Plasmodium falciparumLactonesProteomeProtozoan Proteins

Identifiers

PMID29363540
PMCPMC5855022
OpenAlexW2784489698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.