Evidence map›Paper›PMID 29363525›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus.

Alexa B Schrock, Dean Pavlick, Samuel J Klempner, Jon H Chung, Brady Forcier, Allison Welsh, Lauren Young, Bryan Leyland-Jones, Rodolfo Bordoni, Richard D Carvajal and 9 more

Abstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Clinical utility and applicability of circulating tumor DNA testing in esophageal cancer: a systematic review and meta-analysis.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2022
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  11. Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Alexa B SchrockFoundation Medicine, Inc. Cambridge, Massachusetts. aschrock@foundationmedicine.com.
Dean PavlickFoundation Medicine, Inc. Cambridge, Massachusetts.
Samuel J KlempnerThe Angeles Clinic and Research Institute, Los Angeles, California.
Jon H ChungFoundation Medicine, Inc. Cambridge, Massachusetts.
Brady ForcierFoundation Medicine, Inc. Cambridge, Massachusetts.
Allison WelshFoundation Medicine, Inc. Cambridge, Massachusetts.
Lauren YoungFoundation Medicine, Inc. Cambridge, Massachusetts.
Bryan Leyland-JonesAvera Cancer Institute, Sioux Falls, South Dakota.
Rodolfo BordoniGeorgia Cancer Specialists, Marietta, Georgia.
Richard D CarvajalHerbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
Joseph ChaoDepartment of Medical Oncology and Therapeutics Research, City of Hope, Duarte, California.
Razelle KurzrockMoores Cancer Center, University of California San Diego, La Jolla, California.
Jason K SicklickMoores Cancer Center, University of California San Diego, La Jolla, California.
Jeffrey S RossFoundation Medicine, Inc. Cambridge, Massachusetts.
Philip J StephensFoundation Medicine, Inc. Cambridge, Massachusetts.
Craig DevoeNorthwell Health, Lake Success, New York.
Fadi BraitehComprehensive Cancer Centers of Nevada, Las Vegas, Nevada.
Siraj M AliFoundation Medicine, Inc. Cambridge, Massachusetts.
Vincent A MillerFoundation Medicine, Inc. Cambridge, Massachusetts.

Funding

Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
NCI NIH HHS K08 CA168999
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Biomarkers, TumorCirculating Tumor DNAGenomicsNucleic Acid HybridizationAdultAgedAged, 80 and overAnus NeoplasmsFemaleFollow-Up StudiesGastrointestinal NeoplasmsHumansMaleMiddle AgedMutationNeoplasm GradingBiomarkers, TumorCirculating Tumor DNA

Identifiers

PMID29363525
PMCPMC6076990

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.