ArticleBone & joint research2018
Serum biomarkers in periprosthetic joint infections.
Article in Bone & joint research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 142 citations in OpenAlex.
- Synovial calprotectin in prosthetic joint infection. A systematic review and meta-analysis of the literature.Archives of orthopaedic and trauma surgery · 2024Pooled it
- Synovial fluid calprotectin in diagnosing periprosthetic joint infection: A meta-analysis.International orthopaedics · 2022Pooled it
- Meta-analysis of serum and/or plasma D-dimer in the diagnosis of periprosthetic joint infection.Journal of orthopaedic surgery and research · 2020Pooled it
- Plasma fibrinogen in the diagnosis of periprosthetic joint infection.Scientific reports · 2021Trial
- Retrospective Analysis of Pseudotumor of the Hip: Clinical Management and Outcomes.Orthopaedic surgery · 2026Article
- The accuracy of spectral CT with quantitative parameters in differentiating septic from aseptic periprosthetic complications.Insights into imaging · 2026Article
- Evaluation of Post-operative Serum Biomarkers (D-Dimer, ESR, and CRP) in Patients Following Total Joint Arthroplasty: A Prospective Observational Study.Journal of orthopaedic case reports · 2026Article
- The diagnostic accuracy of serum and synovial inflammatory markers in chronic periprosthetic joint infection among anaemic patients.Bone & joint research · 2026Article
- Global trends in biomarker research for periprosthetic joint infection: a bibliometric analysis.Arthroplasty (London, England) · 2026Article
- Integrated Single-Cell and Bulk RNA Sequencing Reveals the Diagnostic Value of Synovial Tissue Calprotectin and the MDSC-Associated Immune Microenvironment in Periprosthetic Joint Infection.Infection and drug resistance · 2026Article
- Presence of Metallosis Can Interfere With Culture Positivity in Prosthetic Joint Infection of the Hip.Arthroplasty today · 2025Article
- Quantitative Bone SPECT/CT in Diabetic Foot Osteomyelitis: Diagnostic Performance Within-Patient Lesion-Contralateral Separation and Associations with Inflammatory Burden.Diagnostics (Basel, Switzerland) · 2025Article
- [Revision analysis and successful solutions for my failed primary total knee arthroplasties].Orthopadie (Heidelberg, Germany) · 2025Review
- The Ongoing Struggle to Find a Gold Standard for PJI Diagnosis.Reports (MDPI) · 2025Review
- Artificial Intelligence and Its Role in Predicting Periprosthetic Joint Infections.Biomedicines · 2025Review
- Acute phase reactants in the diagnosis of soft tissue infections of the upper extremity.International journal of emergency medicine · 2025Article
- Serum Presepsin Might Not Detect Periprosthetic Joint Infection After Hip Arthroplasty.Journal of clinical medicine · 2025Article
- Article
- Evaluation of Heparin-Binding Protein as a novel biomarker for the detection of periprosthetic joint infection.Frontiers in cellular and infection microbiology · 2025Article
- Periprosthetic Joint Infection (PJI).The archives of bone and joint surgery · 2025Review
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe diagnosis of periprosthetic joint infection (PJI) is difficult and requires a battery of tests and clinical findings. The purpose of this review is to summarize all current evidence for common and new serum biomarkers utilized in the diagnosis of PJI.
methodsWe searched two literature databases, using terms that encompass all hip and knee arthroplasty procedures, as well as PJI and statistical terms reflecting diagnostic parameters. The findings are summarized as a narrative review.
resultsErythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were the two most commonly published serum biomarkers. Most evidence did not identify other serum biomarkers that are clearly superior to ESR and CRP. Other serum biomarkers have not demonstrated superior sensitivity and have failed to replace CRP and ESR as first-line screening tests. D-dimer appears to be a promising biomarker, but more research is necessary. Factors that influence serum biomarkers include temporal trends, stage of revision, and implant-related factors (metallosis).
conclusionOur review helped to identify factors that can influence serum biomarkers' level changes; the recognition of such factors can help improve their diagnostic utility. As such, we cannot rely on ESR and CRP alone for the diagnosis of PJI prior to second-stage reimplantation, or in metal-on-metal or corrosion cases. The future of serum biomarkers will likely shift towards using genomics and proteomics to identify proteins transcribed via messenger RNA in response to infection and sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.