Evidence map›Paper›PMID 29363446›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Safety and Immunogenicity of a Tetravalent Dengue DNA Vaccine Administered with a Cationic Lipid-Based Adjuvant in a Phase 1 Clinical Trial.

Janine R Danko, Tadeusz Kochel, Nimfa Teneza-Mora, Thomas C Luke, Kanakatte Raviprakash, Peifang Sun, Monika Simmons, James E Moon, Rafael De La Barrera, Luis Javier Martinez and 4 more

Open access · greenAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
8.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 82 citations in OpenAlex.

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  6. T Cell Responses During Dengue Infection.Current topics in microbiology and immunology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Janine R DankoInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Tadeusz KochelInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Nimfa Teneza-MoraInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Thomas C LukeInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Kanakatte RaviprakashInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Peifang SunInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Monika SimmonsInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
James E MoonWalter Reed Army Institute of Research, Silver Spring, Maryland.
Rafael De La BarreraWalter Reed Army Institute of Research, Silver Spring, Maryland.
Luis Javier MartinezWalter Reed Army Institute of Research, Silver Spring, Maryland.
Stephen J ThomasWalter Reed Army Institute of Research, Silver Spring, Maryland.
Richard T KenneyClinReg Biologics, LLC, Brisbane, California.
Larry SmithVical Incorporated, San Diego, California.
Kevin R PorterInfectious Diseases Directorate, Naval Medical Research Center, Silver Spring, Maryland.
Naval Medical Research Command · USWalter Reed Army Institute of Research · USVical (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted an open label, dose escalation Phase 1 clinical trial of a tetravalent dengue DNA vaccine (TVDV) formulated in Vaxfectin

Indexed as

Adjuvants, ImmunologicAdultAntibodies, NeutralizingAntibodies, ViralDengueDengue VaccinesDengue VirusFatigueFemaleHeadacheHumansImmunity, CellularImmunization ScheduleImmunogenicity, VaccineInjections, IntramuscularInterferon-gammaAdjuvants, ImmunologicAntibodies, NeutralizingAntibodies, ViralDengue VaccinesInterferon-gammaPhosphatidylethanolaminesVaccines, DNAvaxfectin

Identifiers

PMID29363446
PMCPMC5930886
OpenAlexW2793547630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.