ArticleJournal of enzyme inhibition and medicinal chemistry2018
Synthesis, biological activity and molecular modelling studies of shikimic acid derivatives as inhibitors of the shikimate dehydrogenase enzyme of Escherichia coli.
Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Alkyl shikimates promote proliferation of human dermal fibroblasts and exhibit structure-activity relationships.Scientific reports · 2026Article
- Shikimic acid pathway drives the phase-dependent antibacterial activity of Bacillus amyloliquefaciens against Xanthomonas citri subsp. citri.BMC microbiology · 2026Article
- The antibiofilm effect of shikimic acid in Pseudomonas aeruginosa by interfering the alg D gene.Archives of microbiology · 2026Article
- The Aromatic Amino Acid Biosynthesis GeneMicroorganisms · 2025Article
- Characterization of Natural Products as Inhibitors of Shikimate Dehydrogenase from Methicillin-ResistantBiomolecules · 2025Article
- Commentary on the Obtention of Semi-synthetic Derivatives from Natural Products for Medicinal Applications: Advances, Challenges, and Perspectives.Current medicinal chemistry · 2025Review
- Metabolomic and transcriptomic analyses unveil the accumulation of shikimic acid in the leaves ofFrontiers in plant science · 2025Article
- Identification of potential inhibitors againstJournal of enzyme inhibition and medicinal chemistry · 2024Article
- Structural and Biochemical Analysis of 3-Dehydroquinate Dehydratase fromJournal of microbiology and biotechnology · 2023Article
- MYB transcription factors-master regulators of phenylpropanoid biosynthesis and diverse developmental and stress responses.Plant cell reports · 2022Review
- Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects.Molecules (Basel, Switzerland) · 2022Review
- Artificial cell factory design for shikimate production in Escherichia coli.Journal of industrial microbiology & biotechnology · 2021Article
- Identification of a Novel Therapeutic Target against XDRMicroorganisms · 2021Article
- NICEdrug.ch, a workflow for rational drug design and systems-level analysis of drug metabolism.eLife · 2021Article
- Metabolic engineering of Escherichia coli for production of chemicals derived from the shikimate pathway.Journal of industrial microbiology & biotechnology · 2020Review
- Review
- Amino Acid Biosynthetic Pathways Are Required forAntimicrobial agents and chemotherapy · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shikimic acid (SA) pathway is the common route used by bacteria, plants, fungi, algae, and certain Apicomplexa parasites for the biosynthesis of aromatic amino acids and other secondary metabolites. As this essential pathway is absent in mammals designing inhibitors against implied enzymes may lead to the development of antimicrobial and herbicidal agents harmless to humans. Shikimate dehydrogenase (SDH) is the fourth enzyme of the SA pathway. In this contribution, a series of SA amide derivatives were synthesised and evaluated for in vitro SDH inhibition and antibacterial activity against Escherichia coli. All tested compounds showed to be mixed type inhibitors; diamide derivatives displayed more inhibitory activity than synthesised monoamides. Among the evaluated compounds, molecules called 4a and 4b were the most active derivatives with IC
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