Evidence map›Paper›PMID 29363370›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2018

Sulfonamide inhibition studies of two β-carbonic anhydrases from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2.

Daniela Vullo, Ronny Lehneck, Stefanie Pöggeler, Claudiu T Supuran

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Daniela Vulloa Polo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze , Sesto Fiorentino, Florence , Italy.
Ronny Lehneckb Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms , Georg-August-University Göttingen , Göttingen , Germany.
Stefanie Pöggelerb Institute of Microbiology and Genetics, Department of Genetics of Eukaryotic Microorganisms , Georg-August-University Göttingen , Göttingen , Germany.
Claudiu T Supuranc Neurfarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche , Università degli Studi di Firenze , Sesto Fiorentino, Florence , Italy.
University of Florence · ITUniversity of Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The two β-carbonic anhydrases (CAs, EC 4.2.1.1) recently cloned and purified from the ascomycete fungus Sordaria macrospora, CAS1 and CAS2, were investigated for their inhibition with a panel of 39 aromatic, heterocyclic, and aliphatic sulfonamides and one sulfamate, many of which are clinically used agents. CAS1 was efficiently inhibited by tosylamide, 3-fluorosulfanilamide, and 3-chlorosulfanilamide (K

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesDose-Response Relationship, DrugHyphaeMolecular StructureStructure-Activity RelationshipSulfonamidesCarbonic Anhydrase InhibitorsCarbonic AnhydrasesSulfonamidesCarbonic anhydrasefungusinhibitorSordaria macrosporasulfamatesulfonamide

Identifiers

PMID29363370
PMCPMC6010127
OpenAlexW2787014352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.