Evidence map›Paper›PMID 29363220›Full record

ReviewTransplant international : official journal of the European Society for Organ Transplantation2018

Applying genomics in heart transplantation.

Brendan J Keating, Alexandre C Pereira, Michael Snyder, Brian D Piening

Abstract readReview
In one paragraph

Review in Transplant international : official journal of the European Society for Organ Transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Whole transcriptome profiling of prospective endomyocardial biopsies reveals prognostic and diagnostic signatures of cardiac allograft rejection.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022
    Observational
  4. Article
  5. Cell-free DNA in the surveillance of heart transplant rejection.Indian journal of thoracic and cardiovascular surgery · 2021
    Review
  6. The science and medicine of human immunology.Science (New York, N.Y.) · 2020
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brendan J KeatingDivision of Transplantation, Department of Surgery, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3320-3723
Alexandre C PereiraLaboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.
Michael SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.
Brian D PieningDepartment of Genetics, Stanford University, Stanford, CA, USA.

Funding

Human Genome Array: Technology for Functional AnalysisP50HG002357 · NHGRI · YALE UNIVERSITY · PI SNYDER, MICHAEL P. · 2001 to 2010
$31.9M
Special EquipmentP50HG007735 · NHGRI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2014 to 2018
$15.2M
T32 Training Program in Mechanisms and Innovation in Vascular DiseaseT32HL098049 · NHLBI · STANFORD UNIVERSITY · PI Nicholas James Leeper, Philip S Tsao · 2010 to 2026
$6.3M
NHGRI NIH HHS P50 HG002357NHGRI NIH HHS P50 HG007735NHLBI NIH HHS T32 HL098049
6 · The paper itself

Abstract

While advances in patient care and immunosuppressive pharmacotherapies have increased the lifespan of heart allograft recipients, there are still significant comorbidities post-transplantation and 5-year survival rates are still significant, at approximately 70%. The last decade has seen massive strides in genomics and other omics fields, including transcriptomics, with many of these advances now starting to impact heart transplant clinical care. This review summarizes a number of the key advances in genomics which are relevant for heart transplant outcomes, and we highlight the translational potential that such knowledge may bring to patient care within the next decade.

Indexed as

GenomicsHeart TransplantationBiomarkersGenome-Wide Association StudyHumansPostoperative ComplicationsBiomarkersgenesgenomicshistocompatibility and immunogeneticsimmunobiologymolecular diagnosticproteomics

Identifiers

PMID29363220
PMCPMC5990370

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.