Evidence map›Paper›PMID 29363043›Full record

ArticleMolecular neurobiology2018

Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease.

Lalit Kumar, Shamsuzzama, Pooja Jadiya, Rizwanul Haque, Shikha Shukla, Aamir Nazir

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. CircARID1B Promotes MPPCell biochemistry and biophysics · 2025
    Article
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  10. Article
  11. Article
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  13. Circular RNAs in Brain Physiology and Neurologic Diseases.Advances in experimental medicine and biology · 2025
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  16. Article
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lalit KumarLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India.
ShamsuzzamaLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India.
Pooja JadiyaLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India.
Rizwanul HaqueLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India.
Shikha ShuklaLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India.
Aamir NazirLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology and Experimental Medicine, CSIR-Central Drug Research Institute, Lucknow, UP, 226 031, India. anazir@cdri.res.in.ORCID http://orcid.org/0000-0002-2503-1335
Central Drug Research Institute · IN

Funding

Council of Scientific and Industrial Research 17-06/2012(i)EU-V
6 · The paper itself

Abstract

Circular RNAs (circRNAs) are peculiar non-coding RNA molecules which are known to be present across taxa. Considering the body of evidence that establishes critical functions of non-coding RNA molecules, we endeavored to study circRNAs in the context of Parkinson's disease (PD). Employing transgenic C. elegans model of PD, we used RNase R-mediated cleavage of linear RNA followed by divergent primer-based amplifications towards identifying circzip-2, a novel circRNA molecule. We went on to sequence circzip-2 which is synthesized from functionally important gene zip-2. Studying RNAi-induced knockdown conditions of zip-2, we observed a reduced aggregation of α-synuclein protein along with an enhanced lifespan of the worms. We further carried out transcriptome analysis of zip-2 silenced worms, which suggested that zip-2 might be functioning via Daf-16 pathway. Further interaction studies revealed that circzip-2 possibly sponges microRNA molecule miR-60 towards asserting an important role in various processes associated with PD.

Indexed as

Genes, HelminthAcetylcholineAcetylcholinesterasealpha-SynucleinAnimalsBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegansCaenorhabditis elegans ProteinsDisease Models, AnimalDown-RegulationGene AmplificationGene Knockdown TechniquesLongevityParkinson DiseaseReactive Oxygen SpeciesReproducibility of ResultsAcetylcholineAcetylcholinesterasealpha-SynucleinBasic-Leucine Zipper Transcription FactorsCaenorhabditis elegans ProteinsReactive Oxygen SpeciesRNARNA, CircularZip-2 protein, C elegansC. elegansCircular RNAscirczip-2Parkinson’s diseasezip-2

Identifiers

PMID29363043
OpenAlexW2785081034

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.