Evidence map›Paper›PMID 29362984›Full record

ArticleHuman cell2018

Clinical significance of hWAPL polymorphisms in the risk of cervical carcinogenesis.

Osamu Nunobiki, Daisuke Sano, Sakae Hata, Toshitada Ogasawara, Masatsugu Ueda

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Osamu NunobikiDepartment of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan. o-nunobiki@kobe-tokiwa.ac.jp.ORCID http://orcid.org/0000-0002-3363-8794
Daisuke SanoDepartment of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan.
Sakae HataDepartment of Medical Technology, Kobe Tokiwa University, 6-2 2 chome, Ohtanicho, Nagata-ku, Kobe, Hyogo, 6530838, Japan.
Toshitada OgasawaraDepartment of Obstetrics and Gynecology, Okubo Hospital, Akashi, Hyogo, Japan.
Masatsugu UedaCytopathology and Gynecology, Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan.
Kobe Tokiwa University · JPOgikubo Hospital · JPOsaka International Cancer Institute · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate the clinical significance of human wings apart-like (hWAPL) genetic polymorphisms in cervical carcinogenesis. hWAPL polymorphisms and human papillomavirus (HPV) types were examined in 175 cervical smears of exfoliated cervical cell samples using a real-time polymerase chain reaction system. A significant difference was detected in the frequency of the CC genotype between the HPV(+) low-grade squamous intraepithelial lesion (LSIL) and high-grade squamous intraepithelial lesion (HSIL) groups [Odds ratio 0.21, 95% confidence interval (CI) 0.0723-0.61; P = 0.0029]. A significant difference was noted in the frequency of the CC genotype between the high-risk HPV-positive LSIL and HSIL groups (odds ratio 0.2955, 95% CI 0.0893-0.9771; P = 0.0414). The CC genotype of hWAPL gene promoter polymorphism may be associated with cervical carcinogenesis.

Indexed as

Polymorphism, GeneticCarcinogenesisCarrier ProteinsCervix UteriCohesinsFemaleGenotypeHumansNuclear ProteinsPapillomaviridaePromoter Regions, GeneticProto-Oncogene ProteinsReal-Time Polymerase Chain ReactionRiskSquamous Intraepithelial Lesions of the CervixUterine Cervical NeoplasmsCarrier ProteinsCohesinsNuclear ProteinsProto-Oncogene ProteinsWAPL protein, humanCervical carcinogenesishWAPLPolymorphismSIL

Identifiers

PMID29362984
OpenAlexW2784964731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.