Evidence map›Paper›PMID 29362827›Full record

ArticleEuropean biophysics journal : EBJ2018

Calorimetric markers for monitoring of multiple myeloma and Waldenström's macroglobulinemia patients.

Svetla Todinova, Sashka Krumova, Avgustina Danailova, Violeta Petkova, Margarita Guenova, Georgi Mihaylov, Lidia Gartcheva, Stefka Germanova Taneva

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Article in European biophysics journal : EBJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Svetla TodinovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
Sashka KrumovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
Avgustina DanailovaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
Violeta PetkovaNational Specialized Hospital for Active Treating of Haematological Diseases, Sofia, Bulgaria.
Margarita GuenovaNational Specialized Hospital for Active Treating of Haematological Diseases, Sofia, Bulgaria.
Georgi MihaylovNational Specialized Hospital for Active Treating of Haematological Diseases, Sofia, Bulgaria.
Lidia GartchevaNational Specialized Hospital for Active Treating of Haematological Diseases, Sofia, Bulgaria.
Stefka Germanova TanevaInstitute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria. sgtaneva@gmail.com.
National Specialized Hospital for Active Treatment of Hematologic Diseases · BGBulgarian Academy of Sciences · BGInstitute of Biophysics and Biomedical Engineering · BG

Funding

Bulgarian Academy of Sciences DFNP 140
6 · The paper itself

Abstract

The blood proteome has been studied extensively for identification of novel reliable disease biomarkers. In recent years, differential scanning calorimetry has emerged as a new tool for characterization of the thermodynamic properties of the major serum/plasma proteins and for the establishment of calorimetric markers for a variety of diseases. Here we applied calorimetry to monitor the effect of treatment of patients diagnosed with multiple myeloma and Waldenström's macroglobulinemia on the calorimetric profiles of patients' blood sera. The parameters derived from the calorimetric profiles were compared with the primary serum biomarkers, monoclonal immunoglobulin (M protein) concentration, and κ/λ free light chain ratio. For the secretory cases, the calorimetric parameters thermogram's shape similarity and weighted average center strongly depended on the M protein level but had lower sensitivity and specificity. By contrast, for non-secretory cases, the calorimetric parameters did not depend on the κ/λ free light chains ratio and exhibited significantly higher sensitivity and specificity than M protein levels. A combination of the immunological and calorimetric tests was found to greatly improve the sensitivity and specificity of the clinical status evaluation. The pronounced differences in blood sera thermograms before and during monitoring reflected the individual patients' response to treatment received and showed maintenance of heterogeneity during the disease course.

Indexed as

CalorimetryProteomicsBiomarkers, TumorHumansImmunoglobulinsMultiple MyelomaWaldenstrom MacroglobulinemiaBiomarkers, TumorImmunoglobulinsBlood proteomeCalorimetric parametersDifferential scanning calorimetryFree light chainsMonoclonal immunoglobulinsMultiple myeloma

Identifiers

PMID29362827
OpenAlexW2792651631

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.