ArticleGastroenterology research and practice2017
T Helper Lymphocyte and Mast Cell Immunohistochemical Pattern in Nonceliac Gluten Sensitivity.
Article in Gastroenterology research and practice, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Effects of fructan and gluten on gut microbiota in individuals with self-reported non-celiac gluten/wheat sensitivity-a randomised controlled crossover trial.BMC medicine · 2024Trial
- Review
- Investigating Non-celiac Wheat Sensitivity: A Comprehensive Review of Pathophysiology Underlying Clinical Implications.Clinical reviews in allergy & immunology · 2025Review
- Review
- Fecal calprotectin levels in patients with non-celiac wheat sensitivity: a proof of concept.Internal and emergency medicine · 2024Article
- The Gliadin Hydrolysis Capacity ofNutrients · 2023Article
- Review
- Gluten Induces Subtle Histological Changes in Duodenal Mucosa of Patients with Non-Coeliac Gluten Sensitivity: A Multicentre Study.Nutrients · 2022Article
- Histopathology of non-coeliac gluten sensitivity.Virchows Archiv : an international journal of pathology · 2022Article
- Nutrition in Patients with Lactose Malabsorption, Celiac Disease, and Related Disorders.Nutrients · 2021Review
- Non-Celiac Gluten Sensitivity: An Update.Medicina (Kaunas, Lithuania) · 2021Review
- The Gluten Gene: Unlocking the Understanding of Gluten Sensitivity and Intolerance.The application of clinical genetics · 2021Review
- Coeliac Disease and Mast Cells.International journal of molecular sciences · 2019Review
- Gluten Vehicle and Placebo for Non-Celiac Gluten Sensitivity Assessment.Medicina (Kaunas, Lithuania) · 2019Review
- To Be or Not to Be a Pathogen:Frontiers in immunology · 2019Review
- Predictivity of Autoimmune Stigmata for Gluten Sensitivity in Subjects with Microscopic Enteritis: A Retrospective Study.Nutrients · 2018Article
- Novel steps forward in the histopathology of non-celiac gluten sensitivity.Virchows Archiv : an international journal of pathology · 2018Article
- Novel steps forward in the histopathology of non-celiac gluten sensitivity, authors' reply.Virchows Archiv : an international journal of pathology · 2018Article
- Extra-intestinal manifestations of non-celiac gluten sensitivity: An expanding paradigm.World journal of gastroenterology · 2018Review
- Biological markers for non-celiac gluten sensitivity: a question awaiting for a convincing answer.Gastroenterology and hepatology from bed to bench · 2018Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsNonceliac gluten sensitivity (NCGS) is a gluten-related emerging condition. Since few data about NCGS histopathology is available, we assessed the markers of lymphocyte and innate immunity activation. MATERIALS AND
methodsWe retrieved duodenal biopsy samples of patients with NCGS diagnosis according to the Salerno criteria. We selected specimens of positive (seropositive celiac disease/Marsh 1-2 stage) and negative (normal microscopic picture) controls. Immunohistochemistry for CD3 (intraepithelial lymphocytes-IELs), CD4 (T helper lymphocytes), CD8 (T cytotoxic lymphocytes), and CD1a/CD117 (Langerhans/mast cells) was performed. ANOVA plus Bonferroni's tests were used for statistical analysis.
resultsTwenty NCGS, 16 celiac disease, and 16 negative controls were selected. CD3 in NCGS were higher than negative controls and lower than celiac disease (18.5 ± 6.4, 11.9 ± 2.8, and 40.8 ± 8.1 IELs/100 enterocytes;
conclusionsThe combination of CD4 and CD117, as well as IEL characterization, may be useful to support a clinical diagnosis of NCGS.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.