Evidence map›Paper›PMID 29362520›Full record

ArticleMediators of inflammation2017

Role of Cathepsin S in Periodontal Inflammation and Infection.

S Memmert, A Damanaki, A V B Nogueira, S Eick, M Nokhbehsaim, A K Papadopoulou, A Till, B Rath, S Jepsen, W Götz and 5 more

Abstract read
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
  5. Apelin Enhances the Effects ofInternational journal of molecular sciences · 2023
    Article
  6. Review
  7. Article
  8. The Potential Roles of Dec1 and Dec2 in Periodontal Inflammation.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2020
    Review
  17. Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.American journal of respiratory and critical care medicine · 2019
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

S MemmertSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.ORCID 0000-0002-8153-6610
A DamanakiSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.ORCID 0000-0002-2706-398X
A V B NogueiraDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.ORCID 0000-0002-2756-5947
S EickDepartment of Periodontology, Laboratory for Oral Microbiology, School of Dental Medicine, University of Bern, Bern, Switzerland.ORCID 0000-0002-4619-2461
M NokhbehsaimSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
A K PapadopoulouDiscipline of Orthodontics, Faculty of Dentistry, University of Sydney, Sydney, NSW, Australia.
A TillInstitute of Reconstructive Neurobiology, Life & Brain Center, University of Bonn, Bonn, Germany.ORCID 0000-0002-0139-9143
B RathDepartment of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
S JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University of Bonn, Bonn, Germany.
W GötzDepartment of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
C PiperiDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
E K BasdraDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
J A CirelliDepartment of Diagnosis and Surgery, School of Dentistry at Araraquara, Sao Paulo State University (UNESP), Araraquara, SP, Brazil.ORCID 0000-0002-7082-9290
A JägerDepartment of Orthodontics, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.
J DeschnerSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University of Bonn, Bonn, Germany.ORCID 0000-0002-8808-8769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions elicited by interleukin-1

Indexed as

AdolescentAdultAnimalsAutophagyCathepsinsCells, CulturedChildFemaleGingivaHumansMalePeriodontitisRatsYoung Adultcathepsin SCathepsins

Identifiers

PMID29362520
PMCPMC5736933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.