ArticleScientific reports2018
ATP-mediated Events in Peritubular Cells Contribute to Sterile Testicular Inflammation.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Cell type-specific Ca2+ signals govern mouse seminiferous tubule physiology.PLoS biology · 2026Article
- The Role of Cytokines in the Development and Functioning of the Hypothalamic-Pituitary-Gonadal Axis in Mammals in Normal and Pathological Conditions.International journal of molecular sciences · 2025Review
- Article
- The Relationship Between Tramadol-Induced Oxidative Testis Injury and Reproductive Function Disorder and Adenosine Triphosphate.Life (Basel, Switzerland) · 2025Article
- Biogenic amines in the testis: sources, receptors and actions.Frontiers in endocrinology · 2024Review
- Inactivation of Cops5 in Smooth Muscle Cells Causes Abnormal Reproductive Hormone Homeostasis and Development in Mice.Endocrinology · 2023Article
- The Molecular Signature of Human Testicular Peritubular Cells Revealed by Single-Cell Analysis.Cells · 2022Article
- Article
- Single-cell analysis of human testis aging and correlation with elevated body mass index.Developmental cell · 2022Article
- Purinergic signaling in the male reproductive tract.Frontiers in endocrinology · 2022Review
- Purinergic Signaling in Spermatogenesis.Frontiers in endocrinology · 2022Review
- lncRNA and mRNA sequencing of the left testis in experimental varicocele rats treated withExperimental and therapeutic medicine · 2021Article
- Article
- Regulation of Human Spermatogenesis.Advances in experimental medicine and biology · 2021Article
- Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.Cells · 2020Article
- Palmitic Acid Targets Human Testicular Peritubular Cells and Causes a Pro-Inflammatory Response.Journal of clinical medicine · 2020Article
- Development and function of smooth muscle cells is modulated byDevelopment (Cambridge, England) · 2020Article
- ATP mediates the interaction between human blastocyst and endometrium.Cell proliferation · 2020Article
- Insights into replicative senescence of human testicular peritubular cells.Scientific reports · 2019Article
- CaInternational journal of molecular sciences · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peritubular myoid cells, which form the walls of seminiferous tubules in the testis, are functionally unexplored. While they transport sperm and contribute to the spermatogonial stem cell niche, specifically their emerging role in the immune surveillance of the testis and in male infertility remains to be studied. Recently, cytokine production and activation of Toll-like receptors (TLRs) were uncovered in cultured peritubular cells. We now show that human peritubular cells express purinergic receptors P2RX4 and P2RX7, which are functionally linked to TLRs, with P2RX4 being the prevalent ATP-gated ion channel. Subsequent ATP treatment of cultured peritubular cells resulted in up-regulated (pro-)inflammatory cytokine expression and secretion, while characteristic peritubular proteins, that is smooth muscle cell markers and extracellular matrix molecules, decreased. These findings indicate that extracellular ATP may act as danger molecule on peritubular cells, able to promote inflammatory responses in the testicular environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.