Evidence map›Paper›PMID 29362479›Full record

ReviewCell death and differentiation2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Lorenzo Galluzzi, Ilio Vitale, Stuart A Aaronson, John M Abrams, Dieter Adam, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci, Ivano Amelio, David W Andrews and 159 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death and differentiation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3,990 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3,990citing papers in PubMed, 3 pooled it
203.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3,990 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6,293 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  11. A photothermal ablation strategy for orthotopic ovarian cancerInternational journal of pharmaceutics: X · 2026
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  15. Matrix Metalloproteinase-8 Deficiency Alters the Balance Between Viral Clearance and Immunopathology in H1N1 Infection.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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    Review
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3,930 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

169 authors at 20 institutions in 25 countries.

Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. deadoc@vodafone.it.
Ilio VitaleDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Stuart A AaronsonDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John M AbramsDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dieter AdamInstitute of Immunology, Kiel University, Kiel, Germany.
Patrizia AgostinisCell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Emad S AlnemriDepartment of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.
Lucia AltucciDepartment of Biochemistry, Biophysics and General Pathology, University of Campania "Luigi Vanvitelli", Napoli, Italy.
Ivano AmelioMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
David W AndrewsBiological Sciences, Sunnybrook Research Institute, Toronto, Canada.
Margherita Annicchiarico-PetruzzelliBiochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy.
Alexey V AntonovMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Eli AramaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.
Nickolai A BarlevInstitute of Cytology, Russian Academy of Sciences, Saint-Petersburg, Russia.
Nicolas G BazanNeuroscience Center of Excellence, Louisiana State University School of Medicine, New Orleans, LA, USA.
Francesca BernassolaDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata", Rome, Italy.
Mathieu J M BertrandVIB Center for Inflammation Research (IRC), Ghent, Belgium.
Katiuscia BianchiCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.
Mikhail V BlagosklonnyCell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Klas BlomgrenDepartment of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Christoph BornerInstitute of Molecular Medicine and Cell Research, Albert Ludwigs University, Freiburg, Germany.
Patricia BoyaDepartment of Cellular and Molecular Biology, Center for Biological Investigation (CIB), Spanish National Research Council (CSIC), Madrid, Spain.
Catherine BrennerINSERM U1180, Châtenay Malabry, France.
Michelangelo CampanellaDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Eleonora CandiBiochemistry Laboratory, Dermopatic Institute of Immaculate (IDI) IRCCS, Rome, Italy.
Didac Carmona-GutierrezDepartment Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Francesco CecconiDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Francis K-M ChanDepartment of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.
Navdeep S ChandelDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Emily H ChengHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jerry E ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John A CidlowskiSignal Transduction Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Aaron CiechanoverTechnion Integrated Cancer Center (TICC), The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Gerald M CohenDepartment of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Marcus ConradInstitute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health (GmbH), Munich, Germany.
Juan R Cubillos-RuizSandra and Edward Meyer Cancer Center, New York, NY, USA.
Peter E CzabotarThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Vincenzo D'AngiolellaCancer Research UK and Medical Research Council Institute for Radiation Oncology, Department of Oncology, University of Oxford, Old Road Campus Research Building, Oxford, UK.
Ted M DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Valina L DawsonNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Vincenzo De LaurenziDepartment of Medical, Oral and Biotechnological Sciences, CeSI-MetUniversity of Chieti-Pescara "G. d'Annunzio", Chieti, Italy.
Ruggero De MariaInstitute of General Pathology, Catholic University "Sacro Cuore", Rome, Italy.
Klaus-Michael DebatinDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Mohanish DeshmukhDepartment of Cell Biology and Physiology, Neuroscience Center, University of North Carolina, Chapel Hill, NC, USA.
Nicola Di DanieleHypertension and Nephrology Unit, Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.
Francesco Di VirgilioDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Vishva M DixitDepartment of Physiological Chemistry, Genentech, South San Francisco, CA, USA.
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA, USA.
Colin S DuckettBaylor Scott & White Research Institute, Baylor College of Medicine, Dallas, TX, USA.
Brian D DynlachtDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Wafik S El-DeiryLaboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Hematology/Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
John W ElrodCenter for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine at Temple University School of Medicine, Philadelphia, PA, USA.
Gian Maria FimiaNational Institute for Infectious Diseases IRCCS "Lazzaro Spallanzani", Rome, Italy.
Simone FuldaInstitute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Frankfurt, Germany.
Ana J García-SáezInterfaculty Institute of Biochemistry, Tübingen University, Tübingen, Germany.
Abhishek D GargCell Death Research & Therapy (CDRT) Lab, Department of Cellular & Molecular Medicine, KU Leuven, Leuven, Belgium.
Carmen GarridoINSERM U1231 "Lipides Nutrition Cancer", Dijon, France.
Evripidis GavathiotisDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA.
Pierre GolsteinImmunology Center of Marseille-Luminy, Aix Marseille University, Marseille, France.
Eyal GottliebTechnion Integrated Cancer Center (TICC), The Ruth and Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel.
Douglas R GreenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Lloyd A GreeneDepartment of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Hinrich GronemeyerTeam labeled "Ligue Contre le Cancer", Department of Functional Genomics and Cancer, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France.
Atan GrossDepartment of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
Gyorgy HajnoczkyMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
J Marie HardwickJohns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
Isaac S HarrisDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Michael O HengartnerInstitute of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
Claudio HetzBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
Hidenori IchijoLaboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.
Marja JäätteläCell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
Bertrand JosephToxicology Unit, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Philipp J JostIII Medical Department for Hematology and Oncology, Technical University Munich, Munich, Germany.
Philippe P JuinTeam 8 "Stress adaptation and tumor escape", CRCINA-INSERM U1232, Nantes, France.
William J KaiserDepartment of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center, San Antonio, TX, USA.
Michael KarinLaboratory of Gene Regulation and Signal Transduction, University of California San Diego, La Jolla, CA, USA.
Thomas KaufmannInstitute of Pharmacology, University of Bern, Bern, Switzerland.
Oliver KeppParis Descartes/Paris V University, Paris, France.
Adi KimchiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Richard N KitsisDepartment of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Daniel J KlionskyDepartment of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Richard A KnightMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Sharad KumarCentre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, South Australia, Australia.
Sam W LeeCutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
John J LemastersCenter for Cell Death, Injury and Regeneration, Department of Drug Discovery & Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.
Beth LevineCenter for Autophagy Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Andreas LinkermannDivision of Nephrology, University Hospital Carl Gustav Carus Dresden, Dresden, Germany.
Stuart A LiptonDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Richard A LockshinDepartment of Biology, St. John's University, Queens, NY, USA.
Carlos López-OtínDepartament of Biochemistry and Molecular Biology, Faculty of Medicine, University Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo, Spain.
Scott W LoweHoward Hughes Medical Institute, The Rockefeller University, New York, NY, USA.
Tom LueddeDivision of Gastroenterology, Hepatology and Hepatobiliary Oncology, University Hospital RWTH Aachen, Aachen, Germany.
Enrico LugliLaboratory of Translational Immunology, Humanitas Clinical and Research Center, Rozzano, Milan, Italy.
Marion MacFarlaneMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Frank MadeoDepartment Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Michal MalewiczMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Walter MalorniNational Centre for Gender Medicine, Italian National Institute of Health (ISS), Rome, Italy.
Gwenola ManicDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Jean-Christophe MarineLaboratory for Molecular Cancer Biology, VIB Center for Cancer Biology, Leuven, Belgium.
Seamus J MartinDepartments of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.
Jean-Claude MartinouDepartment of Cell Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Jan Paul MedemaLaboratory for Experimental Oncology and Radiobiology (LEXOR), Center for Experimental Molecular Medicine (CEMM), Academic Medical Center (AMC), University of Amsterdam, Amsterdam, The Netherlands.
Patrick MehlenApoptosis, Cancer and Development laboratory, CRCL, Lyon, France.
Pascal MeierThe Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Mary-Jean Mitchell Green Building, Chester Beatty Laboratories, London, UK.
Sonia MelinoDepartment of Chemical Sciences and Technologies, University of Rome, Tor Vergata, Rome, Italy.
Edward A MiaoDepartment of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.
Jeffery D MolkentinHoward Hughes Medical Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ute M MollDepartment of Pathology, Stony Brook University, Stony Brook, NY, USA.
Cristina Muñoz-PinedoCell Death Regulation Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Hospitalet de Llobregat, Barcelona, Spain.
Shigekazu NagataLaboratory of Biochemistry and Immunology, World Premier International (WPI) Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan.
Gabriel NuñezDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Andrew OberstDepartment of Immunology, University of Washington, Seattle, WA, USA.
Moshe OrenDepartment of Molecular Cell Biology, Weizmann Institute, Rehovot, Israel.
Michael OverholtzerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michele PaganoLaura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
Theocharis PanaretakisDepartment of Genitourinary Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
Manolis PasparakisInstitute for Genetics, Center for Molecular Medicine (CMMC), University of Cologne, Cologne, Germany.
Josef M PenningerInstitute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Campus Vienna BioCentre, Vienna, Austria.
David M PereiraREQUIMTE/LAQV, Laboratory of Pharmacognosy, Department of Chemistry, Faculty of Pharmacy, University of Porto, Porto, Portugal.
Shazib PervaizDepartment of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Marcus E PeterDivision of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Mauro PiacentiniDepartment of Biology, University of Rome "Tor Vergata", Rome, Italy.
Paolo PintonDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Jochen H M PrehnDepartment of Physiology, Royal College of Surgeons in Ireland, Dublin, Ireland.
Hamsa PuthalakathDepartment of Biochemistry, La Trobe University, Victoria, Australia.
Gabriel A RabinovichLaboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME), National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina.
Markus RehmInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Rosario RizzutoDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Cecilia M P RodriguesResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal.
David C RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research (CIMR), University of Cambridge, Cambridge, UK.
Thomas RudelDepartment of Microbiology, Biocenter, University of Würzburg, Würzburg, Germany.
Kevin M RyanCancer Research UK Beatson Institute, Glasgow, UK.
Emre SayanCancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Luca ScorranoDepartment of Biology, University of Padua, Padua, Italy.
Feng ShaoNational Institute of Biological Sciences, Beijing, China.
Yufang ShiKey Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences, Shanghai, China.
John SilkeDepartment of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia.
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, Bern, Switzerland.
Antonella SistiguInstitute of General Pathology, Catholic University "Sacro Cuore", Rome, Italy.
Brent R StockwellDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Andreas StrasserThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Gyorgy SzabadkaiDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Stephen W G TaitCancer Research UK Beatson Institute, Glasgow, UK.
Daolin TangThe Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas Medical School, University of Crete, Heraklion, Greece.
Andrew ThorburnDepartment of Pharmacology, University of Colorado, Aurora, CO, USA.
Yoshihide TsujimotoResearch Center, Osaka International Cancer Institute, Osaka, Japan.
Boris TurkDepartment Biochemistry and Molecular Biology, "Jozef Stefan" Institute, Ljubljana, Slovenia.
Tom Vanden BergheVIB Center for Inflammation Research (IRC), Ghent, Belgium.
Peter VandenabeeleVIB Center for Inflammation Research (IRC), Ghent, Belgium.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andreas VillungerDivision of Developmental Immunology, Innsbruck Medical University, Innsbruck, Austria.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Karen H VousdenFrancis Crick Institute, London, UK.
Domagoj VucicDepartment of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.
Erwin F WagnerGenes, Development and Disease Group, Cancer Cell Biology Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Henning WalczakCentre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.
David WallachDepartment of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.
Ying WangInstitute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
James A WellsDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
Will WoodSchool of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, Bristol, UK.
Junying YuanDepartment of Cell Biology, Harvard Medical School, Boston, MA, USA.
Zahra ZakeriDepartment of Biology, Queens College of the City University of New York, Queens, NY, USA.
Boris ZhivotovskyToxicology Unit, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Laurence ZitvogelFaculty of Medicine, Paris Sud/Paris XI University, Kremlin-Bicêtre, France.
Gerry MelinoMedical Research Council (MRC) Toxicology Unit, Leicester University, Leicester, UK.
Guido KroemerParis Descartes/Paris V University, Paris, France. kroemer@orange.fr.
Weizmann Institute of Science · ILUniversity of Rome Tor Vergata · ITCancer Research UK Scotland Institute · GBMedical Research Council · GBMRC Toxicology Unit · GBAlbert Einstein College of Medicine · USChinese Academy of Sciences · CNColumbia University · USCornell University · USExpert System (Italy) · ITHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · USInserm · FRIstituto Dermopatico dell'Immacolata · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITJohns Hopkins University · USKU Leuven · BEMemorial Sloan Kettering Cancer Center · USNorthwestern University · USQueens College, CUNY · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI Camila dos Santos · 1985 to 2026
$116.8M
Glucocorticoid Hormone ActionZIAES090057 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CIDLOWSKI, JOHN A. · 2009 to 2025
$44.9M
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9M
ALTERNATIVE VACUOLAR TARGETING MECHANISMS IN YEASTR01GM053396 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLIONSKY, DANIEL J. · 1995 to 2018
$12.1M
REGULATION OF THE GI PHASE BY THE UBIQUITIN PATHWAYR01GM057587 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2018
$7.8M
Novel Proteomics Approach to HIV-Associated Neurocognitive Disorder & Drug AbuseDP1DA041722 · NIDA · SCRIPPS RESEARCH INSTITUTE, THE · PI LIPTON, STUART A · 2016 to 2020
$7.0M
Defining the functions and translational potential of ferroptosisR35CA209896 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R. · 2016 to 2022
$6.5M
The mechanism and regulation of autophagyR35GM131919 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DANIEL J. KLIONSKY · 2019 to 2026
$6.4M
Survival Function of the Fadd-Caspase-8-Flip ComplexR01AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI GREEN, DOUGLAS R. · 1999 to 2016
$6.3M
Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT ExtensionR37AI044828 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Douglas R. Green · 2017 to 2026
$4.5M
F-Box Proteins: Deregulated Cell Cycle Control and Proteolysis in CancerR01CA076584 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAGANO, MICHELE · 1998 to 2021
$4.5M
Cancer Research UK 15816Cancer Research UK 18274Cancer Research UK 18278Cancer Research UK 20145Cancer Research UK 22903Medical Research Council MC_PC_12007Medical Research Council MC_U132670600Medical Research Council MC_U132685863Medical Research Council MC_UP_A600_1109Medical Research Council MC_UU_00001/7Medical Research Council MC_UU_00025/4Medical Research Council MR/M019217/1NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA076584NCI NIH HHS R01 CA169291NCI NIH HHS R01 CA178394NCI NIH HHS R01 CA206005NCI NIH HHS R21 CA202200NCI NIH HHS R35 CA209896NHLBI NIH HHS R01 HL123966NHLBI NIH HHS R01 HL136954NHLBI NIH HHS R01 HL142271NIAID NIH HHS R01 AI044828NIAID NIH HHS R37 AI044828NIA NIH HHS P01 AG049665NIA NIH HHS R01 AG056259NIA NIH HHS RF1 AG057409NIDA NIH HHS DP1 DA041722NIGMS NIH HHS R01 GM053396NIGMS NIH HHS R01 GM057587NIGMS NIH HHS R01 GM096208NIGMS NIH HHS R01 GM122923NIGMS NIH HHS R35 GM131919
6 · The paper itself

Abstract

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Indexed as

Cell DeathAnimalsHumansLysosomesMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNecrosisMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition Pore

Identifiers

PMID29362479
PMCPMC5864239
OpenAlexW2788640168

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