ArticleScientific reports2018
Chitin digestibility is dependent on feeding behaviors, which determine acidic chitinase mRNA levels in mammalian and poultry stomachs.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 97 citations in OpenAlex.
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- Nutrient Digestibility, Chitin Recovery and Antioxidant Capacity ofAnimals : an open access journal from MDPI · 2026Article
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- Key Amino Acids Controlling pH Optima in Avian Chia Paralogs: Mechanistic Insights into Functional Divergence.Molecules (Basel, Switzerland) · 2026Article
- Effects of a single-cell protein source fromFrontiers in veterinary science · 2026Article
- Impact of dietary supplementation of black soldier fly larvae (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Effects of moderate-protein and high-protein diets, including mealworm meal or poultry by-product meal, on immunological variables in healthy adult dogs.BMC veterinary research · 2025Article
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- Growth performance, meat quality, cecal microbiota and metabolomics profile of turkeys fed diets containing black soldier fly (Hermetia illucens) meal.Scientific reports · 2025Article
- Impact of Incorporating Defatted Black Soldier Fly Meal into Diet on Growth Performance, Serum Biochemical Parameters, Nutrient Digestibility, Morphology of the Intestinal Tract, and Immune Index of Brooding Laying Hens.Animals : an open access journal from MDPI · 2025Article
- Hyperactivation of human acidic chitinase (Chia) for potential medical use.The Journal of biological chemistry · 2025Article
- Characterisation ofInsects · 2024Article
- Effects of Black Soldier Fly (Insects · 2024Article
- Evolutionary activation of acidic chitinase in herbivores through the H128R mutation in ruminant livestock.iScience · 2023Article
- Gut microbiota changes in insect-fed monogastric species: state-of-the-art and future perspectives.Animal frontiers : the review magazine of animal agriculture · 2023Article
- Insect-based diets (house crickets and mulberry silkworm pupae): A comparison of their effects on canine gut microbiota.Veterinary world · 2023Article
- Molecular characterization and functionality of rumen-derived extracellular vesicles using aJournal of animal science and technology · 2023Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chitin, a polymer of N-acetyl-D-glucosamine (GlcNAc), functions as a major structural component in chitin-containing organism including crustaceans, insects and fungi. Recently, we reported that acidic chitinase (Chia) is highly expressed in mouse, chicken and pig stomach tissues and that it can digest chitin in the respective gastrointestinal tracts (GIT). In this study, we focus on major livestock and domestic animals and show that the levels of Chia mRNA in their stomach tissues are governed by the feeding behavior. Chia mRNA levels were significantly lower in the bovine (herbivores) and dog (carnivores) stomach than those in mouse, pig and chicken (omnivores). Consistent with the mRNA levels, Chia protein was very low in bovine stomach. In addition, the chitinolytic activity of E. coli-expressed bovine and dog Chia enzymes were moderately but significantly lower compared with those of the omnivorous Chia enzymes. Recombinant bovine and dog Chia enzymes can degrade chitin substrates under the artificial GIT conditions. Furthermore, genomes of some herbivorous animals such as rabbit and guinea pig do not contain functional Chia genes. These results indicate that feeding behavior affects Chia expression levels as well as chitinolytic activity of the enzyme, and determines chitin digestibility in the particular animals.
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