Evidence map›Paper›PMID 29362376›Full record

ArticleNature communications2018

A mouse model of autism implicates endosome pH in the regulation of presynaptic calcium entry.

Julie C Ullman, Jing Yang, Michael Sullivan, Jacob Bendor, Jonathan Levy, Ellen Pham, Katlin Silm, Helia Seifikar, Vikaas S Sohal, Roger A Nicoll and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases.Reviews of physiology, biochemistry and pharmacology · 2023
    Article
  10. Article
  11. Review
  12. Wal Mutant Mice Have a Mutation Associated with Autism Spectrum Disorders.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Julie C UllmanDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Jing YangDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Michael SullivanDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Jacob BendorDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Jonathan LevyKavli Institute for Fundamental Neuroscience, UCSF School of Medicine, San Francisco, CA, 94143, USA.ORCID http://orcid.org/0000-0002-8061-7953
Ellen PhamDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Katlin SilmDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Helia SeifikarKavli Institute for Fundamental Neuroscience, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Vikaas S SohalKavli Institute for Fundamental Neuroscience, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Roger A NicollKavli Institute for Fundamental Neuroscience, UCSF School of Medicine, San Francisco, CA, 94143, USA.
Robert H EdwardsDepartments of Neurology and Physiology, UCSF School of Medicine, San Francisco, CA, 94143, USA. robert.edwards@ucsf.edu.ORCID http://orcid.org/0000-0002-8650-3260
University of California, San Francisco · USBerkeley College · US

Funding

The Presynaptic Vesicle Cycle for the Slow Acting Neurotransmitter SecretionP01DA010154 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KREITZER, ANATOL, SULZER, DAVID · 1995 to 2016
$14.7M
NEUROTRANSMITTER EFFECTS ON LOCAL NEURONAL CIRCUITSR37MH038256 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 1987 to 2016
$9.0M
Synaptic Plasticity Regulated by Stargazin-like gamma-8R01MH070957 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NICOLL, ROGER A · 2004 to 2019
$6.3M
TRANSPORT OF NEUROTRANSMITTERS INTO SYNAPTIC VESICLESR01MH050712 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H · 1993 to 2011
$3.8M
Transport of Neurotransmitter Into Synaptic VesiclesR37MH050712 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EDWARDS, ROBERT H · 2012 to 2020
$3.5M
Restoring cognition by optogenetically rescuing gamma rhythms in PFC interneuronsR01MH106507 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOHAL, VIKAAS SINGH · 2015 to 2019
$2.0M
Presynaptic regulation of quantal size by the cation/H+ exchangers NHE6 & NHE9F31MH096447 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ULLMAN, JULIE C · 2011 to 2012
$67k
NIDA NIH HHS P01 DA010154NIMH NIH HHS F31 MH096447NIMH NIH HHS R01 MH050712NIMH NIH HHS R01 MH070957NIMH NIH HHS R01 MH106507NIMH NIH HHS R37 MH038256NIMH NIH HHS R37 MH050712
6 · The paper itself

Abstract

Psychoactive compounds such as chloroquine and amphetamine act by dissipating the pH gradient across intracellular membranes, but the physiological mechanisms that normally regulate organelle pH remain poorly understood. Interestingly, recent human genetic studies have implicated the endosomal Na

Indexed as

AnimalsAttention Deficit Disorder with HyperactivityAutism Spectrum DisorderBehavior, AnimalCalciumDisease Models, AnimalElectroencephalographyEndosomesFemaleGene ExpressionGlutamic AcidHippocampusHumansHydrogen-Ion ConcentrationMaleMiceCalciumGlutamic AcidNHE9 protein, mouseSodium-Hydrogen Exchangers

Identifiers

PMID29362376
PMCPMC5780507
OpenAlexW2803816506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.