Evidence map›Paper›PMID 29361959›Full record

Trial reportCritical care (London, England)2018

Supplemental parenteral nutrition versus usual care in critically ill adults: a pilot randomized controlled study.

Emma J Ridley, Andrew R Davies, Rachael Parke, Michael Bailey, Colin McArthur, Lyn Gillanders, D James Cooper, Shay McGuinness, Supplemental Parenteral Nutrition Clinical Investigators

2 registry-linked trialsOpen access · goldAbstract readClinical Trial, Phase IIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 5 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01847534 phase2 / phase3completednot on this map

Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial

TypeinterventionalSponsorAustralian and New Zealand Intensive Care Research CentreRan2014 to 2016Enrolled100ConditionsMultiple Organ Failure, Critical IllnessArmsSupplemental PN, Standard Care
NCT04607057 phase4unknown statusnot on this mapstarted 2020, after this paper: background citation

The Effect of Postoperative Supplemental Parenteral Nutrition (SPN) in Gastric Cancer Patients Who Underwent Gastrectomy: A Multicenter Prospective Randomized Controlled Trial

TypeinterventionalSponsorSeoul National University HospitalRan2020 to 2022Enrolled224ConditionsGastric Cancer, Gastrectomy, MalnutritionArmsParenteral Nutrition Solutions
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.

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  11. Diagnostic and therapeutic management of severe acute pancreatitis. Evidence based medicine (EBM) clinical practice guidelines.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Emma J RidleyAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia. emma.ridley@monash.edu.
Andrew R DaviesAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia.
Rachael ParkeAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia.
Michael BaileyAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia.
Colin McArthurThe Department of Critical Care Medicine, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand.
Lyn GillandersThe Department of Critical Care Medicine, Auckland City Hospital, Park Road, Grafton, Auckland, New Zealand.
D James CooperAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia.
Shay McGuinnessAustralian and New Zealand Intensive Care Research Centre, School of Public Health and Preventative Medicine, Monash University, Level 3, 553 St Kilda Road, Melbourne, 3004, Australia.
Supplemental Parenteral Nutrition Clinical Investigators
Australian and New Zealand Intensive Care Society · AUAuckland City Hospital · NZMedical Research Institute of New Zealand · NZUniversity of Auckland · NZ

Funding

Baxter Healthcare Corporation n/a
6 · The paper itself

Abstract

backgroundIn the critically ill, energy delivery from enteral nutrition (EN) is often less than the estimated energy requirement. Parenteral nutrition (PN) as a supplement to EN may increase energy delivery. We aimed to determine if an individually titrated supplemental PN strategy commenced 48-72 hours following ICU admission and continued for up to 7 days would increase energy delivery to critically ill adults compared to usual care EN delivery.

methodsThis study was a prospective, parallel group, phase II pilot trial conducted in six intensive care units in Australia and New Zealand. Mechanically ventilated adults with at least one organ failure and EN delivery below 80% of estimated energy requirement in the previous 24 hours received either a supplemental PN strategy (intervention group) or usual care EN delivery. EN in the usual care group could be supplemented with PN if EN remained insufficient after usual methods to optimise delivery were attempted.

resultsThere were 100 patients included in the study and 99 analysed. Overall, 71% of the study population were male, with a mean (SD) age of 59 (17) years, Acute Physiology and Chronic Health Evaluation II score of 18.2 (6.7) and body mass index of 29.6 (5.8) kg/m

conclusionsThis individually titrated supplemental PN strategy applied over 7 days significantly increased energy delivery when compared to usual care delivery. Clinical and functional outcomes were similar between the two patient groups.

trial registrationClinical Trial registry details: NCT01847534 (First registered 22 April 2013, last updated 31 July 2016).

Indexed as

AdultAgedAPACHEAustraliaBody Mass IndexBody Weight MaintenanceCritical IllnessEnergy IntakeFemaleHumansIntensive Care UnitsLength of StayMaleMiddle AgedNew ZealandNutritional StatusClinical nutritionCritical careEnteral nutritionIntensive careNutrition therapyParenteral nutritionRandomized controlled trial

Identifiers

PMID29361959
PMCPMC5781264
OpenAlexW2796184444

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.