ArticleBMC genomics2018
Genetical genomics of growth in a chicken model.
Article in BMC genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 48 citations in OpenAlex.
- Whole-Genome Resequencing Reveals Population Structure and Loci Associated with Growth and Meat-Quality Traits in Meigu Yanying Chickens.Animals : an open access journal from MDPI · 2026Article
- Selection for Tameness in Red Junglefowl Recapitulates Genetic Loci Associated With Domestication-Related Brain Composition.Molecular ecology · 2025Article
- Haplotype-resolved genome and pan-genome graphs reveal the impacts of structural variation on functional genome and feather colors in chickens.iMetaOmics · 2025Article
- Long-Term Heat Stress and Genetic Responses in Growth Traits of Thai Native Synthetic Chicken Lines.Animals : an open access journal from MDPI · 2025Article
- Domestication effects on crowing in chickens: variation between wild and captive red junglefowl and domestic white Leghorn and the genetic architecture of crowing vocalizations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Elucidation of the genetic determination of body weight and size in Chinese local chicken breeds by large-scale genomic analyses.BMC genomics · 2024Article
- Article
- Association analysis of production traits of Japanese quail (Coturnix japonica) using restriction-site associated DNA sequencing.Scientific reports · 2023Article
- Sex proportion as a covariate increases the statistical test power in growth performance based experiments using as-hatched broilers.PloS one · 2023Article
- Genomic and gene expression associations to morphology of a sexual ornament in the chicken.G3 (Bethesda, Md.) · 2022Article
- Intermittent fasting induces chronic changes in the hepatic gene expression of Red Jungle Fowl (Gallus gallus).BMC genomics · 2022Article
- Blood transcriptome comparison between sexes and their function in 4-week Rhode Island red chickens.Animal cells and systems · 2022Article
- Growth performance, survivability and profitability of improved smallholder chicken genetics in Nigeria: A COVID-19 intervention study.Frontiers in genetics · 2022Article
- Jejunal transcriptomic profiling of two layer strains throughout the entire production period.Scientific reports · 2021Article
- Shifts in growth, but not differentiation, foreshadow the formation of exaggerated forms under chicken domestication.Proceedings. Biological sciences · 2021Article
- Characterization of Alternative Splicing (AS) Events during Chicken (Animals : an open access journal from MDPI · 2021Article
- The methylation landscape and its role in domestication and gene regulation in the chicken.Nature ecology & evolution · 2020Article
- Transcriptome Sequencing and Comparative Analysis of Amphoteric ESCs and PGCs in Chicken (Animals : an open access journal from MDPI · 2020Article
- The genetic regulation of size variation in the transcriptome of the cerebrum in the chicken and its role in domestication and brain size evolution.BMC genomics · 2020Article
- Genome-Wide Association Study in Two Cohorts from a Multi-generational Mouse Advanced Intercross Line Highlights the Difficulty of Replication Due to Study-Specific Heterogeneity.G3 (Bethesda, Md.) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe genetics underlying body mass and growth are key to understanding a wide range of topics in biology, both evolutionary and developmental. Body mass and growth traits are affected by many genetic variants of small effect. This complicates genetic mapping of growth and body mass. Experimental intercrosses between individuals from divergent populations allows us to map naturally occurring genetic variants for selected traits, such as body mass by linkage mapping. By simultaneously measuring traits and intermediary molecular phenotypes, such as gene expression, one can use integrative genomics to search for potential causative genes.
resultsIn this study, we use linkage mapping approach to map growth traits (N = 471) and liver gene expression (N = 130) in an advanced intercross of wild Red Junglefowl and domestic White Leghorn layer chickens. We find 16 loci for growth traits, and 1463 loci for liver gene expression, as measured by microarrays. Of these, the genes TRAK1, OSBPL8, YEATS4, CEP55, and PIP4K2B are identified as strong candidates for growth loci in the chicken. We also show a high degree of sex-specific gene-regulation, with almost every gene expression locus exhibiting sex-interactions. Finally, several trans-regulatory hotspots were found, one of which coincides with a major growth locus.
conclusionsThese findings not only serve to identify several strong candidates affecting growth, but also show how sex-specificity and local gene-regulation affect growth regulation in the chicken.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.