Evidence map›Paper›PMID 29361760›Full record

ArticleGenes2018

Using Y-Chromosomal Haplogroups in Genetic Association Studies and Suggested Implications.

A Mesut Erzurumluoglu, Denis Baird, Tom G Richardson, Nicholas J Timpson, Santiago Rodriguez

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

A Mesut ErzurumluogluGenetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK. ame26@leicester.ac.uk.ORCID 0000-0003-1322-8138
Denis BairdMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. denis.baird@bristol.ac.uk.
Tom G RichardsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. tom.g.richardson@bristol.ac.uk.ORCID 0000-0002-7918-2040
Nicholas J TimpsonMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. n.j.timpson@bristol.ac.uk.
Santiago RodriguezMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK. santi.rodriguez@bristol.ac.uk.ORCID 0000-0001-6551-932X

Funding

Medical Research Council G0600705Medical Research Council G1001799Medical Research Council MC_UU_12013/3Medical Research Council MR/K002767/1Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/S003886/1Wellcome Trust 202802/Z/16/Z
6 · The paper itself

Abstract

Y-chromosomal (Y-DNA) haplogroups are more widely used in population genetics than in genetic epidemiology, although associations between Y-DNA haplogroups and several traits, including cardiometabolic traits, have been reported. In apparently homogeneous populations defined by principal component analyses, there is still Y-DNA haplogroup variation which will result from population history. Therefore, hidden stratification and/or differential phenotypic effects by Y-DNA haplogroups could exist. To test this, we hypothesised that stratifying individuals according to their Y-DNA haplogroups before testing for associations between autosomal single nucleotide polymorphisms (SNPs) and phenotypes will yield difference in association. For proof of concept, we derived Y-DNA haplogroups from 6537 males from two epidemiological cohorts, Avon Longitudinal Study of Parents and Children (ALSPAC) (

Indexed as

1958 Birth CohortAvon Longitudinal Study of Parents and Childrenbody mass indexhaplogroupsY-DNA

Identifiers

PMID29361760
PMCPMC5793196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.