ArticleInternational journal of molecular sciences2018
Identification of a Rare Germline Heterozygous Deletion Involving the Polycistronic miR-17-92 Cluster in Two First-Degree Relatives from a BRCA 1/2 Negative Chilean Family with Familial Breast Cancer: Possible Functional Implications.
Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- A Single Variant in Pri-miRNA-155 Associated with Susceptibility to Hereditary Breast Cancer Promotes Aggressiveness in Breast Cancer Cells.International journal of molecular sciences · 2022Article
- miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer.Cell cycle (Georgetown, Tex.) · 2020Article
- The dual functional role of MicroRNA-18a (miR-18a) in cancer development.Clinical and translational medicine · 2019Review
- The MicroRNA Family Both in Normal Development and in Different Diseases: The miR-17-92 Cluster.BioMed research international · 2019Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Micro-RNAs (miRNAs) have emerged as novel gene expression regulators. Recent evidence strongly suggests a role for miRNAs in a large variety of cancer-related pathways. Different studies have shown that 18.7 to 37% of all human miRNA genes are clustered. miR-17-92 polycistronic cluster overexpression is associated with human hematolymphoid and solid malignancies including breast cancer (BC). Here, we report the identification of rs770419845, a rare 6 bp deletion located within the polycistronic miR-17-92 cluster, in two first-degree relatives from a Chilean family with familial BC and negative for point mutations in
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