Evidence map›Paper›PMID 29361587›Full record

ArticleThe Journal of experimental biology2018

Biomechanical mechanisms underlying exosuit-induced improvements in walking economy after stroke.

Jaehyun Bae, Louis N Awad, Andrew Long, Kathleen O'Donnell, Katy Hendron, Kenneth G Holt, Terry D Ellis, Conor J Walsh

3 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of experimental biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04818424 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Robotic Exosuit Augmented Locomotion (REAL) in the Clinic and Community

TypeinterventionalSponsorLou Awad, PT, DPT, PhDRan2021 to 2022Enrolled0ConditionsStrokeArmsSoft exosuit, Gait training without exosuits
NCT05315310 nacompletednot on this mapstarted 2022, after this paper: background citation

Robotic Exosuit Augmented Locomotion (REAL) in the Clinic and Community - a Mechanistic Clinical Trial

TypeinterventionalSponsorBoston University Charles River CampusRan2022 to 2023Enrolled26ConditionsStrokeArmsSoft Exosuit
NCT07212608 nacompletednot on this mapstarted 2022, after this paper: background citation

Wearable Gait Interventions for Augmenting Paretic Propulsion: Towards Personalized Post-Stroke Gait Rehabilitation

TypeinterventionalSponsorBoston University Charles River CampusRan2022 to 2025Enrolled22ConditionsStrokeArmsSoft robotic exosuit, Propulsion neuroprosthesis
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  15. Advances on mechanical designs for assistive ankle-foot orthoses.Frontiers in bioengineering and biotechnology · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jaehyun BaePaulson School of Engineering and Applied Sciences, Harvard University, 60 Oxford Street, Cambridge, MA 02138, USA.ORCID 0000-0002-7300-4518
Louis N AwadPaulson School of Engineering and Applied Sciences, Harvard University, 60 Oxford Street, Cambridge, MA 02138, USA.ORCID 0000-0002-0159-8011
Andrew LongPaulson School of Engineering and Applied Sciences, Harvard University, 60 Oxford Street, Cambridge, MA 02138, USA.
Kathleen O'DonnellPaulson School of Engineering and Applied Sciences, Harvard University, 60 Oxford Street, Cambridge, MA 02138, USA.
Katy HendronDepartment of Physical Therapy & Athletic Training, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA.
Kenneth G HoltDepartment of Physical Therapy & Athletic Training, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA.
Terry D EllisDepartment of Physical Therapy & Athletic Training, Boston University, 635 Commonwealth Avenue, Boston, MA 02215, USA walsh@seas.harvard.edu tellis@bu.edu.ORCID 0000-0001-7067-4527
Conor J WalshPaulson School of Engineering and Applied Sciences, Harvard University, 60 Oxford Street, Cambridge, MA 02138, USA walsh@seas.harvard.edu tellis@bu.edu.ORCID 0000-0002-2744-917X
Boston University · USHarvard University · US

Funding

Institutional Career DevelopmentKL2TR001411 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MORONE, NATALIA E. · 2015 to 2024
$5.9M
NCATS NIH HHS KL2 TR001411
6 · The paper itself

Abstract

Stroke-induced hemiparetic gait is characteristically asymmetric and metabolically expensive. Weakness and impaired control of the paretic ankle contribute to reduced forward propulsion and ground clearance - walking subtasks critical for safe and efficient locomotion. Targeted gait interventions that improve paretic ankle function after stroke are therefore warranted. We have developed textile-based, soft wearable robots that transmit mechanical power generated by off-board or body-worn actuators to the paretic ankle using Bowden cables (soft exosuits) and have demonstrated the exosuits can overcome deficits in paretic limb forward propulsion and ground clearance, ultimately reducing the metabolic cost of hemiparetic walking. This study elucidates the biomechanical mechanisms underlying exosuit-induced reductions in metabolic power. We evaluated the relationships between exosuit-induced changes in the body center of mass (COM) power generated by each limb, individual joint power and metabolic power. Compared with walking with an exosuit unpowered, exosuit assistance produced more symmetrical COM power generation during the critical period of the step-to-step transition (22.4±6.4% more symmetric). Changes in individual limb COM power were related to changes in paretic (

Indexed as

RoboticsAdultAnkleBiomechanical PhenomenaEnergy MetabolismFemaleGaitHumansMaleMiddle AgedParesisStroke RehabilitationWalkingExoskeletonGait biomechanicsGait energeticsPost-stroke gaitRoboticsStroke rehabilitation

Identifiers

PMID29361587
PMCPMC5868931
OpenAlexW2783689185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.