Evidence map›Paper›PMID 29361575›Full record

ArticleDevelopment (Cambridge, England)2018

Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression.

Sophie Colombo, Carmen de Sena-Tomás, Vanessa George, Andreas A Werdich, Sunil Kapur, Calum A MacRae, Kimara L Targoff

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. The second heart field: the first 20 years.Mammalian genome : official journal of the International Mammalian Genome Society · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Bixafen causes cardiac toxicity in zebrafish (Danio rerio) embryos.Environmental science and pollution research international · 2021
    Article
  16. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021
    Review
  17. Atrial and Sinoatrial Node Development in the Zebrafish Heart.Journal of cardiovascular development and disease · 2021
    Review
  18. Thyroid Hormone Receptor α Mutations Cause Heart Defects in Zebrafish.Thyroid : official journal of the American Thyroid Association · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sophie ColomboDivision of Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-8945-5631
Carmen de Sena-TomásDivision of Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Vanessa GeorgeDivision of Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.ORCID 0000-0003-1990-4651
Andreas A WerdichBrigham and Women's Hospital/Harvard Medical School, Cardiovascular Division, 75 Francis Street, Thorn 11, Boston, MA 02115, USA.ORCID 0000-0002-1222-1180
Sunil KapurBrigham and Women's Hospital/Harvard Medical School, Cardiovascular Division, 75 Francis Street, Thorn 11, Boston, MA 02115, USA.
Calum A MacRaeBrigham and Women's Hospital/Harvard Medical School, Cardiovascular Division, 75 Francis Street, Thorn 11, Boston, MA 02115, USA.ORCID 0000-0001-5181-2664
Kimara L TargoffDivision of Cardiology, Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA kl284@columbia.edu.ORCID 0000-0002-6066-6002
Columbia University · USBrigham and Women's Hospital · US

Funding

A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
CHILD HEALTH RESEARCH CENTER CAREER DEVELOPMENT AWARDK12HD043389 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DRISCOLL, JOHN M · 2003 to 2007
$2.2M
Mechanisms of second heart field development regulated by Nkx genesR01HL131438 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TARGOFF, KIMARA L · 2017 to 2021
$2.1M
Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the HeartR00HL112724 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WERDICH, ANDREAS AUGUSTINUS · 2015 to 2018
$747k
Regulation of cardiac morphogenesis by Nkx genes in the zebrafish embryoK08HL088002 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TARGOFF, KIMARA L · 2007 to 2010
$517k
NHLBI NIH HHS K08 HL088002NHLBI NIH HHS R00 HL112724NHLBI NIH HHS R01 HL131438NICHD NIH HHS K12 HD043389NIH HHS R24 OD017870
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAnimals, Genetically ModifiedBody PatterningCell DifferentiationCell ProliferationGene Expression Regulation, DevelopmentalHeartHeart Defects, CongenitalHomeobox Protein Nkx-2.5Homeodomain ProteinsHumansLIM-Homeodomain ProteinsMutationMyoblasts, CardiacTranscription FactorsZebrafish ProteinsHomeobox Protein Nkx-2.5Homeodomain Proteinsinsulin gene enhancer binding protein Isl-1LIM-Homeodomain ProteinsNkx2.5 protein, zebrafishNkx2.7 protein, zebrafishTranscription FactorsZebrafish ProteinsArterial polenkx2.5nkx2.7Second heart fieldVenous poleZebrafish

Identifiers

PMID29361575
PMCPMC5818010
OpenAlexW2781040421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.