Evidence map›Paper›PMID 29361533›Full record

ArticleJournal of cell science2018

Role of membrane-tension gated Ca

Lijuan He, Jiaxiang Tao, Debonil Maity, Fangwei Si, Yi Wu, Tiffany Wu, Vishnu Prasath, Denis Wirtz, Sean X Sun

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Mechanical models and measurement methods of solid stress in tumors.Applied microbiology and biotechnology · 2024
    Review
  8. Review
  9. Review
  10. Review
  11. CaCellular signalling · 2023
    Review
  12. Article
  13. Article
  14. Article
  15. Hydrostatic pressure as a driver of cell and tissue morphogenesis.Seminars in cell & developmental biology · 2022
    Review
  16. Extracellular Hydraulic Resistance Enhances Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Lijuan HeDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Jiaxiang TaoDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Debonil MaityDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Fangwei SiDepartment of Physics, University of California San Diego, San Diego, CA 92010, USA.
Yi WuDepartment of Cell Biology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Tiffany WuDepartment of Molecular and Cellular Biology, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Vishnu PrasathDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Denis WirtzDepartment of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Sean X SunDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA ssun@jhu.edu.ORCID 0000-0002-9077-7088
Johns Hopkins University · USUConn Health · USUniversity of California San Diego · US

Funding

Imaging Tools to Visualize and Manipulate Signaling in Minute Spaces (Admin Supp)R01GM117061 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI WU, YI · 2016 to 2020
$2.0M
The Role of Osmotic Engine in Confined MigrationR01GM114675 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KONSTANTOPOULOS, KONSTANTINOS, SUN, SEAN X · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM114675NIGMS NIH HHS R01 GM117061
6 · The paper itself

Abstract

Eukaryotic cells are sensitive to mechanical forces they experience from the environment. The process of mechanosensation is complex, and involves elements such as the cytoskeleton and active contraction from myosin motors. Ultimately, mechanosensation is connected to changes in gene expression in the cell, known as mechanotransduction. While the involvement of the cytoskeleton in mechanosensation is known, the processes upstream of cytoskeletal changes are unclear. In this paper, by using a microfluidic device that mechanically compresses live cells, we demonstrate that Ca

Indexed as

Mechanical PhenomenaCalcium SignalingCell Cycle ProteinsCell LineCell MembraneCytoplasmCytoskeletonHumansLab-On-A-Chip DevicesMechanotransduction, CellularMuscle ContractionMyosinsNuclear ProteinsOsmotic Pressurerho GTP-Binding ProteinsTranscription FactorsCell Cycle ProteinsMyosinsNuclear Proteinsrho GTP-Binding ProteinsTranscription FactorsYY1AP1 protein, humanCa2+ channelsCell cortexMechanosensationTension-activated channel

Identifiers

PMID29361533
PMCPMC5868948
OpenAlexW2952931170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.