Evidence map›Paper›PMID 29361530›Full record

ArticleJournal of cell science2018

Non-equivalence of nuclear import among nuclei in multinucleated skeletal muscle cells.

Alicia A Cutler, Jennifer B Jackson, Anita H Corbett, Grace K Pavlath

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Exercise metabolism and adaptation in skeletal muscle.Nature reviews. Molecular cell biology · 2023
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Modeling the transport of nuclear proteins along single skeletal muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Transitional Hybrid Skeletal Muscle Fibers in Rat Soleus Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alicia A CutlerDepartment of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Jennifer B JacksonDepartment of Pharmacology, Emory University, Atlanta, GA 30322, USA.
Anita H CorbettDepartment of Biology, Emory University, Atlanta, GA 30322, USA gpavlat@emory.edu acorbe2@emory.edu.
Grace K PavlathDepartment of Pharmacology, Emory University, Atlanta, GA 30322, USA gpavlat@emory.edu acorbe2@emory.edu.ORCID 0000-0002-5623-205X
Emory University · US

Funding

Training Program in Biochemistry, Cell and Molecular BiologyT32GM008367 · NIGMS · EMORY UNIVERSITY · PI BOISE, LAWRENCE H., CORBETT, ANITA H. · 1990 to 2019
$5.6M
Muscle-Specific Basis of OPMDR01AR061987 · NIAMS · EMORY UNIVERSITY · PI CORBETT, ANITA H. · 2011 to 2021
$3.4M
Nucleocytoplasmic Transport in Skeletal MuscleR01AR062483 · NIAMS · EMORY UNIVERSITY · PI PAVLATH, GRACE K · 2012 to 2016
$1.7M
Interplay between nuclear import and transcriptional activity during myogenesisF31AR067645 · NIAMS · EMORY UNIVERSITY · PI CUTLER, ALICIA A · 2015 to 2017
$128k
NIAMS NIH HHS F31 AR067645NIAMS NIH HHS R01 AR061987NIAMS NIH HHS R01 AR062483NIGMS NIH HHS T32 GM008367
6 · The paper itself

Abstract

Skeletal muscle is primarily composed of large myofibers containing thousands of post-mitotic nuclei distributed throughout a common cytoplasm. Protein production and localization in specialized myofiber regions is crucial for muscle function. Myonuclei differ in transcriptional activity and protein accumulation, but how these differences among nuclei sharing a cytoplasm are achieved is unknown. Regulated nuclear import of proteins is one potential mechanism for regulating transcription spatially and temporally in individual myonuclei. The best-characterized nuclear localization signal (NLS) in proteins is the classical NLS (cNLS), but many other NLS motifs exist. We examined cNLS and non-cNLS reporter protein import using multinucleated muscle cells generated

Indexed as

Active Transport, Cell NucleusAmino Acid SequenceAnimalsCell DifferentiationCell NucleusCells, CulturedMaleMice, Inbred C57BLMuscle CellsMuscle DevelopmentMuscle Fibers, SkeletalMuscle, SkeletalNuclear Localization SignalsReceptors, Cytoplasmic and NuclearNuclear Localization SignalsReceptors, Cytoplasmic and NuclearcNLSMyofiberMyonucleiMyotube

Identifiers

PMID29361530
PMCPMC5826044
OpenAlexW2777323942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.