Evidence map›Paper›PMID 29361512›Full record

ArticleDisease models & mechanisms2018

Environmental factors regulate Paneth cell phenotype and host susceptibility to intestinal inflammation in Irgm1-deficient mice.

Allison R Rogala, Alexi A Schoenborn, Brian E Fee, Viviana A Cantillana, Maria J Joyce, Raad Z Gharaibeh, Sayanty Roy, Anthony A Fodor, R Balfour Sartor, Gregory A Taylor and 1 more

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Allison R RogalaCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Alexi A SchoenbornCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Brian E FeeGeriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC 27705, USA.
Viviana A CantillanaDepartments of Medicine; Molecular Genetics and Microbiology; and Immunology; Division of Geriatrics, and Center for the Study of Aging and Human Development, Duke University Medical Center, Durham, NC 27710, USA.
Maria J JoyceDepartment of Medicine, Division of Infectious Disease, Duke University Medical Center, Durham, NC 27710, USA.
Raad Z GharaibehDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
Sayanty RoyCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anthony A FodorCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
R Balfour SartorCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gregory A TaylorGeriatric Research, Education, and Clinical Center, VA Medical Center, Durham, NC 27705, USA.
Ajay S GulatiCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA ajay_gulati@med.unc.edu.ORCID 0000-0002-7612-6369
University of North Carolina at Chapel Hill · USDuke University · USUniversity of North Carolina at Charlotte · USDuke Medical Center · USGeriatric Research Education and Clinical Center · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Role of IL-10 in APC Regulation of Protective vs. Pathogenic T Cell Responses toP01DK094779 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SARTOR, RYAN B · 2013 to 2023
$17.9M
National Gnotobiotic Rodent Resource CenterP40OD010995 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Ryan B Sartor · 2012 to 2026
$9.7M
GASTROENTEROLOGY RESEARCH TRAININGT32DK007737 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SHEHZAD Z. SHEIKH · 1996 to 2026
$7.8M
Regulation of IFN-g-induced Innate Immunity by LRG-47R01AI057831 · NIAID · DUKE UNIVERSITY · PI TAYLOR, GREGORY A · 2004 to 2013
$3.1M
Paneth cell dysfunction and gut dysbiosis in experimental intestinal inflammationK08DK095917 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GULATI, AJAY S · 2012 to 2014
$463k
Influences of the enteric microbiota on intestinal stem cell biologyR03DK104005 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GULATI, AJAY S · 2015 to 2016
$152k
Regulation of Intestinal Inflammation by Irgm1I01BX002369 · VA · DURHAM VA MEDICAL CENTER · PI TAYLOR, GREGORY A · 2015 to 2018
–
BLRD VA I01 BX002369NIAID NIH HHS R01 AI057831NIDDK NIH HHS K08 DK095917NIDDK NIH HHS P01 DK094779NIDDK NIH HHS P30 DK034987NIDDK NIH HHS R03 DK104005NIDDK NIH HHS T32 DK007737NIH HHS P40 OD010995
6 · The paper itself

Abstract

Crohn's disease (CD) represents a chronic inflammatory disorder of the intestinal tract. Several susceptibility genes have been linked to CD, though their precise role in the pathogenesis of this disorder remains unclear. Immunity-related GTPase M (

Indexed as

EnvironmentAnimalsBiodiversityCell ProliferationColitisDextran SulfateDisease SusceptibilityEpithelial CellsGastrointestinal MicrobiomeGenotypeGoblet CellsGTP-Binding ProteinsHelicobacterInflammationIntestinesMice, KnockoutDextran SulfateGTP-Binding ProteinsIfi1 protein, mouseExperimental colitisImmunity-related GTPasesInflammatory bowel diseases

Identifiers

PMID29361512
PMCPMC5894938
OpenAlexW2779773246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.