Evidence map›Paper›PMID 29361510›Full record

ArticleThe journal of allergy and clinical immunology. In practice

Asthma and Allergic Disorders in Uganda: A Population-Based Study Across Urban and Rural Settings.

Brooks W Morgan, Trishul Siddharthan, Matthew R Grigsby, Suzanne L Pollard, Robert Kalyesubula, Robert A Wise, Bruce Kirenga, William Checkley

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PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of allergy and clinical immunology. In practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Risk factors associated with rhinitis, allergic conjunctivitis and eczema among schoolchildren in Uganda.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brooks W MorganDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md.
Trishul SiddharthanDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md.
Matthew R GrigsbyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md.
Suzanne L PollardDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md.
Robert KalyesubulaDepartment of Medicine and Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Robert A WiseDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md.
Bruce KirengaDepartment of Medicine and Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
William CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Md; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Md. Electronic address: wcheckl1@jhmi.edu.

Funding

Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
FIC NIH HHS R25 TW009340NHLBI NIH HHS HHSN268200900033C
6 · The paper itself

Abstract

backgroundAllergic diseases are increasing in sub-Saharan Africa, but few studies have characterized the burden among adults.

objectiveWe conducted a study to evaluate the prevalence and risk factors of allergic disorders in urban and rural Uganda.

methodsWe present a cross-sectional analysis of enrollment data from a population-based cohort study of adults aged ≥35 years in urban and rural Uganda. Sociodemographic and both lifetime and 12-month respiratory symptoms data were collected and spirometry was conducted following standard guidelines.

resultsIn 1,308 adults (median age 43.8 years and 52.3% female), we found an age-adjusted prevalence of 6.8% for asthma (9.8% urban, 4.3% rural; P < .001), 11.9% for allergic rhinitis (16.4% urban, 7.8% rural; P < .001), and 8.2% for eczema (9.9% urban, 7.8% rural; P = .15). Urbanization was the primary driver of asthma, accounting for 61.4% of cases (95% confidence interval [CI] 22.0% to 83.4%), and was the strongest risk factor for any allergic illness (odds ratio [OR] = 1.87, 95% CI 1.39-2.51). Parental asthma was not associated with allergic illness. Asthma was associated with a lower forced expiratory volume in 1 second (FEV

conclusionsAsthma and allergic rhinitis were twice as prevalent in urban settings. Asthma was associated with greater impairment and worse lung function outcomes. We identified a high prevalence of allergic disorders in Uganda, which can be expected to increase due to urbanization and resultant exposures throughout early development.

Indexed as

Rural PopulationUrban PopulationAdultAsthmaCohort StudiesCross-Sectional StudiesFemaleHumansHypersensitivityMaleMiddle AgedPrevalenceRisk FactorsSpirometryUgandaAllergiesAsthmaEczemaEpidemiologyPopulation attributable fractionRhinitisRisk factorsSub-Saharan AfricaUganda

Identifiers

PMID29361510
PMCPMC6050146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.