Evidence map›Paper›PMID 29361303›Full record

ArticleThe Journal of thoracic and cardiovascular surgery2018

Virtual surgical planning, flow simulation, and 3-dimensional electrospinning of patient-specific grafts to optimize Fontan hemodynamics.

Dominik Siallagan, Yue-Hin Loke, Laura Olivieri, Justin Opfermann, Chin Siang Ong, Diane de Zélicourt, Anastasios Petrou, Marianne Schmid Daners, Vartan Kurtcuoglu, Mirko Meboldt and 5 more

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In one paragraph

Article in The Journal of thoracic and cardiovascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  3. A Novel Prenatal Pipeline for Three-Dimensional Hemodynamic Modeling of the Fetal Aorta.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Dominik SiallaganSheikh Zayed Institute for Surgical Innovation, Children's National Medical Center, Washington, DC; Product Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Yue-Hin LokeDivision of Cardiology, Children's National Health System, Washington, DC.
Laura OlivieriSheikh Zayed Institute for Surgical Innovation, Children's National Medical Center, Washington, DC; Division of Cardiology, Children's National Health System, Washington, DC.
Justin OpfermannSheikh Zayed Institute for Surgical Innovation, Children's National Medical Center, Washington, DC.
Chin Siang OngDivision of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Md.
Diane de ZélicourtThe Interface Group, Institute of Physiology, University of Zürich, Zurich, Switzerland; Swiss National Centre of Competence in Research, Kidney Control of Homeostasis, Zurich, Switzerland.
Anastasios PetrouProduct Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Marianne Schmid DanersProduct Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Vartan KurtcuogluThe Interface Group, Institute of Physiology, University of Zürich, Zurich, Switzerland; Swiss National Centre of Competence in Research, Kidney Control of Homeostasis, Zurich, Switzerland.
Mirko MeboldtProduct Development Group Zurich, Department of Mechanical and Process Engineering, ETH Zurich, Zurich, Switzerland.
Kevin NelsonNanofiber Solutions, Inc, Hilliard, Ohio.
Luca VricellaDivision of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Md.
Jed JohnsonNanofiber Solutions, Inc, Hilliard, Ohio.
Narutoshi HibinoDivision of Cardiac Surgery, Johns Hopkins Hospital, Baltimore, Md. Electronic address: nhibino1@jhmi.edu.
Axel KriegerSheikh Zayed Institute for Surgical Innovation, Children's National Medical Center, Washington, DC; Department of Mechanical Engineering, University of Maryland, College Park, Md.

Funding

Training Program in Cellular and Molecular MedicineT32GM008752 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI RAO, RAJINI · 2000 to 2019
$11.7M
Patient Specific Tissue Engineered Vascular Graft Creation Using 3D Printing TechnologyR21HD090671 · NICHD · JOHNS HOPKINS UNIVERSITY · PI HIBINO, NARUTOSHI, KRIEGER, AXEL · 2017 to 2018
$484k
NICHD NIH HHS R21 HD090671NIGMS NIH HHS T32 GM008752
6 · The paper itself

Abstract

backgroundDespite advances in the Fontan procedure, there is an unmet clinical need for patient-specific graft designs that are optimized for variations in patient anatomy. The objective of this study is to design and produce patient-specific Fontan geometries, with the goal of improving hepatic flow distribution (HFD) and reducing power loss (P

methodsCardiac magnetic resonance imaging data from patients who previously underwent a Fontan procedure (n = 2) was used to create 3-dimensional models of their native Fontan geometry using standard image segmentation and geometry reconstruction software. For each patient, alternative designs were explored in silico, including tube-shaped and bifurcated conduits, and their performance in terms of P

resultsCFD simulations showed that the bifurcated conduit improved HFD between the left and right pulmonary arteries, whereas both types of conduits reduced P

conclusionsOur unique virtual cardiac surgery approach has the potential to improve the quality of surgery by manufacturing patient-specific designs before surgery, that are also optimized with balanced HFD and minimal P

Indexed as

Blood Vessel ProsthesisComputer-Aided DesignHemodynamicsPatient-Specific ModelingPrinting, Three-DimensionalProsthesis DesignBlood Vessel Prosthesis ImplantationFontan ProcedureHeart Defects, CongenitalHumansHydrodynamicsMagnetic Resonance AngiographyModels, CardiovascularPredictive Value of TestsPulmonary ArteryPulmonary Circulation3D printingflow dynamicspatient specific modelvirtual surgical planning

Identifiers

PMID29361303
PMCPMC5860962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.