Evidence map›Paper›PMID 29361173›Full record

ArticleJournal of the National Cancer Institute2018

The Changing Face of Noncardia Gastric Cancer Incidence Among US Non-Hispanic Whites.

William F Anderson, Charles S Rabkin, Natalie Turner, Joseph F Fraumeni, Philip S Rosenberg, M Constanza Camargo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 11 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 11 syntheses or guidelines pooled it, 260 citations in OpenAlex.

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  10. Laparoscopic versus open gastrectomy for gastric cancer.World journal of surgical oncology · 2020
    Pooled it
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  12. Trial
  13. Microbiology and molecular biology reviews : MMBR · 2026
    Review
  14. Article
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  20. Racial and Ethnic Differences in Gastric Cancer by Stage of Diagnosis in the United States (2009-2019).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
    Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

William F AndersonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Charles S RabkinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Natalie TurnerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Joseph F FraumeniDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Philip S RosenbergDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
M Constanza CamargoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.
Division of Cancer Epidemiology and GeneticsNational Cancer Institute · US

Funding

Methods for Epidemiology StudiesZIACP010181 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBERT, PAUL · 2009 to 2025
$34.8M
6 · The paper itself

Abstract

Background: The initial step for noncardia gastric carcinogenesis is atrophic gastritis, driven by either Helicobacter pylori infection or autoimmunity. In recent decades, the prevalence rates of these two major causes declined and increased, respectively, with changes in Western lifestyles. We therefore assessed gastric cancer incidence trends for US race/ethnic groups, 1995-2013. Methods: Age-standardized rates (ASRs) from 45 North American Association of Central Cancer Tumor Registries were summarized by estimated annual percentage change (EAPC) and 95% confidence intervals (CIs). Age period cohort models supplemented standard descriptive techniques and projected future trends. Results: There were 137 447 noncardia cancers in 4.4 billion person-years of observation. Among non-Hispanic whites, the ASR was 2.2 per 100 000 person-years, with an EAPC of -2.3% (95% CI = -2.0% to -2.6%). Notwithstanding this overall decline, EAPCs rose 1.3% (95% CI = 0.6% to 2.1%) for persons younger than age 50 years and fell -2.6% (95% CI = -2.4% to -2.9%) for older individuals. These converging trends manifested a birth cohort effect more pronounced among women than men, with incidence among women born in 1983 twofold (95% CI = 1.1-fold to 3.6-fold) greater than those born in 1951. Age interaction was also statistically significant among Hispanic whites, with slightly increasing vs decreasing EAPCs for younger and older individuals, respectively. Incidence declined regardless of age for other races. Current trends foreshadow expected reversals in both falling incidence and male predominance among non-Hispanic whites. Conclusions: Dysbiosis of the gastric microbiome associated with modern living conditions may be increasing risk of autoimmune gastritis and consequent noncardia cancer. The changing face by age and sex of gastric cancer warrants analytical studies to identify potential causal mechanisms.

Indexed as

AdultAgedAged, 80 and overCohort StudiesEthnicityFemaleHelicobacter InfectionsHumansIncidenceMaleMiddle AgedPrevalenceRacial GroupsRegistriesStomach NeoplasmsUnited States

Identifiers

PMID29361173
PMCPMC6005150
OpenAlexW2790011499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.