ArticleToxicological sciences : an official journal of the Society of Toxicology2018
Glutathione S-Transferase Protein Expression in Different Life Stages of Zebrafish (Danio rerio).
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 64 citations in OpenAlex.
- The single and combined effects of deltamethrin and polyethylene microplastics on the development and biochemical responses of Xenopus laevis in early life stages.Ecotoxicology (London, England) · 2026Article
- Low dose ionising radiation elicits MPTP comparable alterations in locomotor Function, oxidative balance and mitochondrial homeostasis in zebrafish embryos.Scientific reports · 2025Article
- Thymol and menthol as anaesthetics for short transportation of zebrafish larva.Fish physiology and biochemistry · 2025Article
- miR-10-5p mediated susceptibility to chlorantraniliprole by targeting for SfGSTe1 in Spodoptera frugiperda (Smith).Scientific reports · 2025Article
- Comparative characterization of organ-specific phase I and II biotransformation enzyme kinetics in salmonid S9 sub-cellular fractions and cell lines.Cell biology and toxicology · 2025Article
- Article
- First Identification of a Large Set of Serine Hydrolases by Activity-Based Protein Profiling in Dibutyl Phthalate-Exposed Zebrafish Larvae.International journal of molecular sciences · 2022Article
- Article
- DNA methylation and mRNA expression of glutathione S-transferase alpha 4 are associated with intracranial aneurysms in a gender-dependent manner.Frontiers in genetics · 2022Article
- The chemical defensome of five model teleost fish.Scientific reports · 2021Article
- GlutathioneThe Journal of pharmacology and experimental therapeutics · 2021Article
- Transcriptomic Diversity in the Livers of South African Sardines Participating in the Annual Sardine Run.Genes · 2021Article
- Teratogenic, Oxidative Stress and Behavioural Outcomes of Three Fungicides of Natural Origin (Toxics · 2021Article
- Expression analysis of glutathione S-transferases and ferritins during the embryogenesis of the tickHeliyon · 2020Article
- Mapping glutathione utilization in the developing zebrafish (Danio rerio) embryo.Redox biology · 2019Article
- MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.Redox biology · 2018Article
- Metabolism of five diterpenoid lactones fromRSC advances · 2018Article
- Proteomic Responses Under Cold Stress Reveal Unique Cold Tolerance Mechanisms in the Pacific White Shrimp (Frontiers in physiology · 2018Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zebrafish is a widely used animal model in biomedical sciences and toxicology. Although evidence for the presence of phases I and II xenobiotic defense mechanisms in zebrafish exists on the transcriptional and enzyme activity level, little is known about the protein expression of xenobiotic metabolizing enzymes. Given the important role of glutathione S-transferases (GSTs) in phase II biotransformation, we analyzed cytosolic GST proteins in zebrafish early life stages and different organs of adult male and female fish, using a targeted proteomics approach. The established multiple reaction monitoring-based assays enable the measurement of the relative abundance of specific GST isoenzymes and GST classes in zebrafish through a combination of proteotypic peptides and peptides shared within the same class. GSTs of the classes alpha, mu, pi and rho are expressed in zebrafish embryo as early as 4 h postfertilization (hpf). The majority of GST enzymes are present at 72 hpf followed by a continuous increase in expression thereafter. In adult zebrafish, GST expression is organ dependent, with most of the GST classes showing the highest expression in the liver. The expression of a wide range of cytosolic GST isoenzymes and classes in zebrafish early life stages and adulthood supports the use of zebrafish as a model organism in chemical-related investigations.
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