Evidence map›Paper›PMID 29360884›Full record

SynthesisPloS one2018

Relationship between socioeconomic status and gastrointestinal infections in developed countries: A systematic review and meta-analysis.

Natalie L Adams, Tanith C Rose, Jeremy Hawker, Mara Violato, Sarah J O'Brien, Benjamin Barr, Victoria J K Howard, Margaret Whitehead, Ross Harris, David C Taylor-Robinson

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
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  5. The Prevalence ofMedicina (Kaunas, Lithuania) · 2025
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  18. Sampling and Sampling Frames in Big Data Epidemiology.Current epidemiology reports · 2019
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Natalie L AdamsNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Tanith C RoseNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.ORCID 0000-0001-5338-0359
Jeremy HawkerNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Mara ViolatoNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Sarah J O'BrienNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Benjamin BarrNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Victoria J K HowardDepartment of Public Health and Policy, University of Liverpool, Liverpool, United Kingdom.
Margaret WhiteheadNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
Ross HarrisNational Infection Service, Public Health England, London, United Kingdom.
David C Taylor-RobinsonNIHR Health Protection Research Unit in Gastrointestinal Infections, Liverpool, United Kingdom.
University of Liverpool · GBPublic Health England · GB

Funding

Medical Research Council MR/P008577/1
6 · The paper itself

Abstract

backgroundThe association between socioeconomic status (SES) and health is well-documented; however limited evidence on the relationship between SES and gastrointestinal (GI) infections exists, with published studies producing conflicting results. This systematic review aimed to assess the association between SES and GI infection risk, and explore possible sources of heterogeneity in effect estimates reported in the literature.

methodsMEDLINE, Scopus, Web of Science and grey literature were searched from 1980 to October 2015 for studies reporting an association between GI infections and SES in a representative population sample from a member-country of the Organisation for Economic Co-operation and Development. Harvest plots and meta-regression were used to investigate potential sources of heterogeneity such as age; level of SES variable; GI infection measurement; and predominant mode of transmission. The protocol was registered on PROSPERO: CRD42015027231.

resultsIn total, 6021 studies were identified; 102 met the inclusion criteria. Age was identified as the only statistically significant potential effect modifier of the association between SES and GI infection risk. For children, GI infection risk was higher for those of lower SES versus high (RR 1.51, 95% CI;1.26-1.83), but there was no association for adults (RR 0.79, 95% CI;0.58-1.06). In univariate analysis, the increased risk comparing low and high SES groups was significantly higher for pathogens spread by person-to-person transmission, but lower for environmental pathogens, as compared to foodborne pathogens.

conclusionsDisadvantaged children, but not adults, have greater risk of GI infection compared to their more advantaged counterparts. There was high heterogeneity and many studies were of low quality. More high quality studies are needed to investigate the association between SES and GI infection risk, and future research should stratify analyses by age and pathogen type. Gaining further insight into this relationship will help inform policies to reduce inequalities in GI illness in children.

Indexed as

Social ClassDeveloped CountriesGastrointestinal DiseasesHumansInfections

Identifiers

PMID29360884
PMCPMC5779704
OpenAlexW2789799059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.