ArticlePloS one2018
Characterization of plasmids harboring blaCTX-M and blaCMY genes in E. coli from French broilers.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 39 citations in OpenAlex.
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- Molecular Characterization and Antibiotic Resistance of Broad-SpectrumInternational journal of microbiology · 2026Article
- On the Difficulty to Detect Carbapenem Resistance in the Environment: Characterisation of Escherichia coli With Reduced Carbapenem Susceptibility Isolated in a French River.Environmental microbiology reports · 2025Article
- Phenotypic and Genomic Assessment of Antimicrobial Resistance and Virulence Factors Determinants inAnimals : an open access journal from MDPI · 2025Article
- Comparison of IncK-Antibiotics (Basel, Switzerland) · 2024Article
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- Comparative Genomic Analysis of Antimicrobial-ResistantMicroorganisms · 2022Article
- Diversity of blaCTX-M-1-carrying plasmids recovered from Escherichia coli isolated from Canadian domestic animals.PloS one · 2022Article
- Epidemiological and genomic characteristics of globalFrontiers in microbiology · 2022Article
- Characterization of antibiotic resistance in Escherichia coli isolates from Black-headed gulls (Larus ridibundus) present in the city of Novi Sad, Serbia.Veterinary research communications · 2021Article
- Characterization ofMicroorganisms · 2021Article
- High prevalence of blaScientific reports · 2021Article
- Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-ProducingFrontiers in microbiology · 2021Article
- High occurrence of CMY-2-type beta-lactamase-producing Escherichia coli among broiler flocks in Turkey.Tropical animal health and production · 2020Article
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- Bacteriocin Occurrence and Activity inToxins · 2019Article
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- Development of a pig infection model with colistin-resistant Escherichia coli.Veterinary microbiology · 2018Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance to extended-spectrum cephalosporins (ESC) is a global health issue. The aim of this study was to analyze and compare plasmids coding for resistance to ESC isolated from 16 avian commensal and 17 avian pathogenic Escherichia coli (APEC) strains obtained respectively at slaughterhouse or from diseased broilers in 2010-2012. Plasmid DNA was used to transform E. coli DH5alpha, and the resistances of the transformants were determined. The sequences of the ESC-resistance plasmids prepared from transformants were obtained by Illumina (33 plasmids) or PacBio (1 plasmid). Results showed that 29 of these plasmids contained the blaCTX-M-1 gene and belonged to the IncI1/ST3 type, with 27 and 20 of them carrying the sul2 or tet(A) genes respectively. Despite their diverse origins, several plasmids showed very high percentages of identity. None of the blaCTX-M-1-containing plasmid contained APEC virulence genes, although some of them were detected in the parental strains. Three plasmids had the blaCMY-2 gene, but no other resistance gene. They belonged to IncB/O/K/Z-like or IncFIA/FIB replicon types. The blaCMY-2 IncFIA/FIB plasmid was obtained from a strain isolated from a diseased broiler and also containing a blaCTX-M-1 IncI1/ST3 plasmid. Importantly APEC virulence genes (sitA-D, iucA-D, iutA, hlyF, ompT, etsA-C, iss, iroB-E, iroN, cvaA-C and cvi) were detected on the blaCMY-2 plasmid. In conclusion, our results show the dominance and high similarity of blaCTX-M-1 IncI1/ST3 plasmids, and the worrying presence of APEC virulence genes on a blaCMY-2 plasmid.
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