ArticleBritish journal of cancer2018
Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study.
Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Light at night exposure and risk of breast cancer: a meta-analysis of observational studies.Frontiers in public health · 2023Pooled it
- Light at night and risk of breast cancer: a systematic review and dose-response meta-analysis.International journal of health geographics · 2021Pooled it
- Pooled it
- Chronotherapy in Oncology: Aligning Cancer Treatment with Biological Time.Journal of personalized medicine · 2026Review
- PI3 K/AKT/mTOR pathway and its role in breast cancer stem cells.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Exposure to Light at Night and Risk of Cancer: A Systematic Review, Meta-Analysis, and Data Synthesis.Cancers · 2024Review
- Digital Screen Time and the Risk of Female Breast Cancer: A Retrospective Matched Case-Control Study.Journal of biomedical physics & engineering · 2024Article
- Breast cancer: Epidemiology, risk factors and screening.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2023Article
- Circadian Disruption and Breast Cancer Risk: Evidence from a Case-Control Study in China.Cancers · 2023Article
- Light at night and the risk of breast cancer: Findings from the Sister study.Environment international · 2022Article
- Triple-Negative Breast Cancer: A Brief Review About Epidemiology, Risk Factors, Signaling Pathways, Treatment and Role of Artificial Intelligence.Frontiers in molecular biosciences · 2022Review
- Review
- Associations of long-term exposure to environmental noise and outdoor light at night with age at natural menopause in a US women cohort.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Exposure to artificial light at night and risk of cancer: where do we go from here?British journal of cancer · 2021Article
- Clock at the Core of Cancer Development.Biology · 2021Review
- Shift Work and Breast Cancer.International journal of environmental research and public health · 2020Review
- Light Pollution and Cancer.International journal of molecular sciences · 2020Review
- Circadian disruption: What do we actually mean?The European journal of neuroscience · 2020Review
- Mummy Induces Apoptosis Through Inhibiting of Epithelial-Mesenchymal Transition (EMT) in Human Breast Cancer Cells.Galen medical journal · 2020Article
- Night shift work and risk of breast cancer in women: the Generations Study cohort.British journal of cancer · 2019Article
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6 authors.
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Abstract
backgroundCircadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological or case-control in design and findings have been mixed.
methodsWe investigated the relationship between LAN and breast cancer risk in the UK Generations Study. Bedroom light levels and sleeping patterns at age 20 and at study recruitment were obtained by questionnaire. Analyses were conducted on 105 866 participants with no prior history of breast cancer. During an average of 6.1 years of follow-up, 1775 cases of breast cancer were diagnosed. Cox proportional hazard models were used to calculate hazard ratios (HRs), adjusting for potential confounding factors.
resultsThere was no association between LAN level and breast cancer risk overall (highest compared with lowest LAN level at recruitment: HR=1.01, 95% confidence interval (CI): 0.88-1.15), or for invasive (HR=0.98, 95% CI: 0.85-1.13) or in situ (HR=0.96, 95% CI: 0.83-1.11) breast cancer, or oestrogen-receptor (ER) positive (HR=0.98, 95% CI: 0.84-1.14); or negative (HR=1.16, 95% CI: 0.82-1.65) tumours separately. The findings did not differ by menopausal status. Adjusting for sleep duration, sleeping at unusual times (non-peak sleep) and history of night work did not affect the results. Night waking with exposure to light, occurring around age 20, was associated with a reduced risk of premenopausal breast cancer (HR for breast cancer overall=0.74, 95% CI: 0.55-0.99; HR for ER-positive breast cancer=0.69, 95% CI: 0.49-0.97).
conclusionsIn this prospective cohort analysis of LAN, there was no evidence that LAN exposure increased the risk of subsequent breast cancer, although the suggestion of a lower breast cancer risk in pre-menopausal women with a history of night waking in their twenties may warrant further investigation.
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