Evidence map›Paper›PMID 29360809›Full record

ArticlePediatric research2018

Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis.

Kezhen Huang, Subhajit Mukherjee, Vera DesMarais, Joseph M Albanese, Ektor Rafti, Andrew Draghi Ii, Leigh A Maher, Kamal M Khanna, Sridhar Mani, Adam P Matson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Article
  3. Necrotizing enterocolitis.Nature reviews. Disease primers · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. The Physiology of Enteric Glia.Annual review of physiology · 2025
    Review
  15. Review
  16. Hepatoprotective effects ofIranian journal of basic medical sciences · 2025
    Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kezhen HuangDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut.
Subhajit MukherjeeDepartment of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York.
Vera DesMaraisDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York.
Joseph M AlbaneseDepartment of Pathology, Montefiore Medical Center, Bronx, New York.
Ektor RaftiDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut.
Andrew Draghi IiDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut.
Leigh A MaherDepartment of Immunology, University of Connecticut School of Medicine, Farmington, Connecticut.
Kamal M KhannaDepartment of Microbiology, New York University Langone School of Medicine, New York, New York.
Sridhar ManiDepartment of Medicine and Genetics, Albert Einstein College of Medicine, Bronx, New York.
Adam P MatsonDepartment of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut.
University of Connecticut · USAlbert Einstein College of Medicine · USMontefiore Medical Center · USNew York University · US

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI STEVEN C. ALMO · 1985 to 2026
$111.2M
Development of Novel Drugs to Alleviate CPT-11 ToxicityR01CA161879 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MANI, SRIDHAR, REDINBO, MATTHEW R · 2012 to 2016
$1.6M
High-speed/resolution whole slide scanner supported by two core facilitiesS10OD019961 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI CONDEELIS, JOHN S · 2015 to 2015
$326k
NCI NIH HHS P30 CA013330NCI NIH HHS R01 CA161879NIH HHS S10 OD019961
6 · The paper itself

Abstract

BackgroundThere is substantial evidence that signaling through Toll-like receptor 4 (TLR4) contributes to the pathogenesis of necrotizing enterocolitis (NEC). Pregnane X receptor (PXR), a xenobiotic sensor and signaling intermediate for certain host-bacterial metabolites, has been shown to negatively regulate TLR4 signaling. Here we investigated the relationship between PXR and TLR4 in the developing murine intestine and explored the capacity of PXR to modulate inflammatory pathways involved in experimental NEC.MethodsWild-type and PXR

Indexed as

Signal TransductionAnimalsCrosses, GeneticDactinomycinDisease Models, AnimalEnterocolitis, NecrotizingFemaleGene Expression RegulationHumansInflammationIntestinesLipopolysaccharidesMaleMiceMice, Inbred C57BLMice, KnockoutDactinomycinLipopolysaccharidesNR1I2 protein, humanNr1i2 protein, mousePregnane X ReceptorRNA, MessengerTLR4 protein, humanTlr4 protein, mouseToll-Like Receptor 4

Identifiers

PMID29360809
PMCPMC5959752
OpenAlexW2790403733

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.