Evidence map›Paper›PMID 29360805›Full record

ArticlePediatric research2018

Mild cerebellar injury does not significantly affect cerebral white matter microstructural organization and neurodevelopmental outcome in a contemporary cohort of preterm infants.

Richelle E M Senden, Kristin Keunen, Niek E van der Aa, Alexander Leemans, Ivana Isgum, Max A Viergever, Jeroen Dudink, Linda S de Vries, Floris Groenendaal, Manon J N L Benders

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Pediatric research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Richelle E M SendenDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Kristin KeunenDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Niek E van der AaDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Alexander LeemansBrain Center Rudolf Magnus, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Ivana IsgumBrain Center Rudolf Magnus, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Max A ViergeverBrain Center Rudolf Magnus, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Jeroen DudinkDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Linda S de VriesDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Floris GroenendaalDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
Manon J N L BendersDepartment of Neonatology, University Medical Center Utrecht and Utrecht University, Utrecht, The Netherlands.
University Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundPreterm birth is associated with an increased risk of cerebellar injury. The aim of this study was to assess the impact of cerebellar hemorrhages (CBH) on cerebral white matter microstructural tissue organization and cerebellar volume at term-equivalent age (TEA) in extremely preterm infants. Furthermore, we aimed to evaluate the association between CBH and neurodevelopmental outcome in late infancy.MethodsA total of 24 preterm infants with punctate CBH were included and each matched to two preterm control infants. T1-, T2-weighted images and diffusion-weighted imaging were acquired on a 3T magnetic resonance imaging (MRI) system. Regions of interest were drawn on a population-specific neonatal template and automatically registered to individual fractional anisotropy (FA) maps. Brain volumes were automatically computed. Neurodevelopmental outcome was assessed using the Bayley scales of Infant and Toddler Development at 2 years of corrected age.ResultsCBHs were not significantly related to FA in the posterior limb of the internal capsule and corpus callosum or to cerebellar volume. Infants with CBH did not have poorer neurodevelopmental outcome compared with control infants.ConclusionThese findings suggest that the impact of mild CBH on early macroscale brain development may be limited. Future studies are needed to assess the effects of CBH on long-term neurodevelopment.

Indexed as

AnisotropyBrainBrain MappingCase-Control StudiesCerebellumChild, PreschoolCohort StudiesDiffusion Magnetic Resonance ImagingFemaleGestational AgeHumansImage Processing, Computer-AssistedInfantInfant, NewbornInfant, PrematureMagnetic Resonance Imaging

Identifiers

PMID29360805
OpenAlexW2789939235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.