Evidence map›Paper›PMID 29360768›Full record

ArticleInternational journal of molecular sciences2018

Pharmacokinetic Study of Bioactive Flavonoids in the Traditional Japanese Medicine Keigairengyoto Exerting Antibacterial Effects against Staphylococcus aureus.

Takashi Matsumoto, Atsushi Kaneko, Junichi Koseki, Yosuke Matsubara, Setsuya Aiba, Kenshi Yamasaki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Antioxidative and Immunomodulating Properties ofPlants (Basel, Switzerland) · 2022
    Article
  3. Article
  4. Article
  5. Article
  6. Evidence-based complementary and alternative medicine : eCAM · 2021
    Article
  7. Review
  8. Article
  9. Bioactive Phenolics and Polyphenols: Current Advances and Future Trends.International journal of molecular sciences · 2020
    Article
  10. Article
  11. Article
  12. Tellimagrandin II, A Type of Plant Polyphenol Extracted fromInternational journal of molecular sciences · 2019
    Article
  13. Review
  14. Article
  15. Anti-inflammatory and antibacterial potential of Ajwa date (Journal of advanced pharmaceutical technology & research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Takashi MatsumotoTsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki 300-1192, Japan. matsumoto_takashi@mail.tsumura.co.jp.ORCID 0000-0003-2653-5372
Atsushi KanekoTsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki 300-1192, Japan. kaneko_atsushi@mail.tsumura.co.jp.
Junichi KosekiTsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki 300-1192, Japan. htkj9626m@mineo.jp.
Yosuke MatsubaraTsumura Kampo Research Laboratories, Kampo Research & Development Division, Tsumura & Co., Ibaraki 300-1192, Japan. matsubara_yousuke@mail.tsumura.co.jp.
Setsuya AibaDepartment of Dermatology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan. saiba@med.tohoku.ac.jp.
Kenshi YamasakiDepartment of Dermatology, Tohoku University Graduate School of Medicine, Miyagi 980-8574, Japan. kyamasaki@med.tohoku.ac.jp.
Tsumura Research Institute (Japan) · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent studies have demonstrated that flavonoid glucuronides can be deconjugated to the active form aglycone by β-glucuronidase-expressing macrophages. Keigairengyoto (KRT) is a flavonoid-rich traditional Japanese medicine reported to enhance bacterial clearance through immune modulation. Our aims are to examine the pharmacokinetics of KRT flavonoids and to identify active flavonoids contributing to the adjuvant effects of KRT. KRT was evaluated at pharmacokinetic analysis to quantify absorbed flavonoids, and cutaneous infection assay induced in mice by inoculation of

Indexed as

AnimalsAnti-Bacterial AgentsChromatography, High Pressure LiquidFlavonoidsGlucuronidesMacrophagesMedicine, TraditionalMolecular StructurePhagocytosisPhytochemicalsPlant ExtractsRatsStaphylococcal InfectionsStaphylococcal Skin InfectionsStaphylococcus aureusAnti-Bacterial AgentsFlavonoidsGlucuronidesPhytochemicalsPlant Extractsbacterial infectionflavonoidKeigairengyotomacrophagesphagocytosispharmacokineticsStaphylococcus aureus

Identifiers

PMID29360768
PMCPMC5855550
OpenAlexW2793649128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.