ArticlePsychosomatic medicine2018
The Influence of Environmental Enrichment on Cardiovascular and Behavioral Responses to Social Stress.
Article in Psychosomatic medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Voluntary exercise is a moderately effective mitigator of chronic social isolation stress in two female rodent models.Physiology & behavior · 2025Article
- Environmental enrichment for laboratory rats and mice: endocrine, physiological, and behavioral benefits of meeting rodents' biological needs.Frontiers in veterinary science · 2025Review
- Protective effects of exercise on responses to combined social and environmental stress in prairie voles.Annals of the New York Academy of Sciences · 2025Article
- Targeted environmental enrichment is more effective than bipedal treadmill training after thoracic spinal cord injury.Brain communications · 2025Article
- Prairie voles as a model for adaptive reward remodeling following loss of a bonded partner.Annals of the New York Academy of Sciences · 2024Review
- The Influence of Environmental Enrichment on Affective and Neural Consequences of Social Isolation Across Development.Affective science · 2022Article
- Intimate partner violence: psycho-physio-pathological sequelae for defining a holistic enriched treatment.Frontiers in behavioral neuroscience · 2022Article
- Mean Girls: Social Stress Models for Female Rodents.Current topics in behavioral neurosciences · 2022Review
- Differential paraventricular nucleus activation and behavioral responses to social isolation in prairie voles following environmental enrichment with and without physical exercise.Social neuroscience · 2021Article
- Efficacy of choline and DHA supplements or enriched environment exposure during early adult obesity in mitigating its adverse impact through aging in rats.Saudi journal of biological sciences · 2021Article
- Protective neuroendocrine effects of environmental enrichment and voluntary exercise against social isolation: evidence for mediation by limbic structures.Stress (Amsterdam, Netherlands) · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveStress is linked to negative cardiovascular consequences and increases in depressive behaviors. Environmental enrichment (EE) involves exposure to novel items that provide physical and cognitive stimulation. EE has behavioral, cognitive, and neurobiological effects that may improve stress responses in humans and animal models. This study investigated the potential protective effects of EE on behavior and cardiovascular function in female prairie voles after a social stressor.
methodsRadiotelemetry transmitters were implanted into female prairie voles to measure heart rate (HR) and heart rate variability (HRV) throughout the study. All females were paired with a male partner for 5 days, followed by separation from their partner for 5 additional days, and a 10-day treatment period. Treatment consisted of continued isolation, isolation with EE, or re-pairing with the partner (n = 9 per group). After treatment, animals were observed in the forced swim test (FST) for measures of stress coping behaviors.
resultsIsolation elevated HR and reduced HRV relative to baseline for all groups (p < .001). HR and HRV returned to baseline in the EE and re-paired groups, but not in the continued isolation group (p < .001). Animals in the EE and re-paired groups displayed significantly lower immobility time (p < .001) and HR (p < .03) during the FST, with a shorter latency for HR to return to baseline levels after the FST, relative to the continued isolation group (p < .001).
conclusionsEE and re-pairing reversed the negative behavioral and cardiovascular consequences associated with social isolation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.