ArticleThe journal of pain2018
Resting Functional Connectivity of the Periaqueductal Gray Is Associated With Normal Inhibition and Pathological Facilitation in Conditioned Pain Modulation.
Article in The journal of pain, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Structural and Functional Neuroimaging Findings in Fibromyalgia: A Systematic Review.European journal of pain (London, England) · 2026Pooled it
- Greater Somatosensory Afference With Acupuncture Increases Primary Somatosensory Connectivity and Alleviates Fibromyalgia Pain via Insular γ-Aminobutyric Acid: A Randomized Neuroimaging Trial.Arthritis & rheumatology (Hoboken, N.J.) · 2021Trial
- Pressure Pain Tolerance Predicts the Success of Emotional Awareness and Expression Therapy in Patients With Fibromyalgia.The Clinical journal of pain · 2020Trial
- Changes in hormones and experimental pain sensitivity in healthy girls: an exploratory longitudinal pilot study.Pain reports · 2026Article
- The Impact of Sex on the Dysfunction of Endogenous Pain Control after Traumatic Brain Injury.Journal of neurotrauma · 2026Article
- Visual Hypersensitivity as a Transdiagnostic Marker of Surgical Pain Response in Arthritis and Chronic Pain Syndromes.Arthritis & rheumatology (Hoboken, N.J.) · 2026Article
- Fibromyalgia: A Multifactorial Pain Disorder.International journal of molecular sciences · 2026Review
- Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level.Brain : a journal of neurology · 2026Article
- Sensing vs. seeing: body experience rather than mere body observation is linked to efficiency of descending pain modulation.Scientific reports · 2026Article
- Differential Alterations in Offset Analgesia and Conditioned Pain Modulation in Fibromyalgia: Evidence for Distinct Central Dysregulation.European journal of pain (London, England) · 2026Article
- Moving Toward Objective Diagnosis in Fibromyalgia: Emerging Biomarkers and Digital Phenotyping Tools.Biomedicines · 2026Review
- Conditioned pain modulation, cortical imbalance, and arthrogenic muscle inhibition: an integrative model with implications for exercise in chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Conditioned Pain Modulation, Placebo and Offset Analgesia: Rates of Behavioural Expression of Inhibitory, Nonresponse and Facilitatory Pain Modulatory Effects.European journal of pain (London, England) · 2025Article
- Quantitative Sensory Testing in Fibromyalgia Syndrome: A Scoping Review.Biomedicines · 2025Review
- Conditioned pain modulation elicited through manual pressure techniques on the cervical spine: a crossover study.Pain reports · 2025Article
- Innovations in acute and chronic pain biomarkers: enhancing diagnosis and personalized therapy.Regional anesthesia and pain medicine · 2025Review
- Can electroencephalography (EEG) identify the different dimensions of pain in fibromyalgia? A pilot study.BMC musculoskeletal disorders · 2024Article
- Designer Receptor Exclusively Activated by Designer Drug (DREADD)-Mediated Activation of the Periaqueductal Gray Restores Nociceptive Descending Inhibition After Traumatic Brain Injury in Rats.Journal of neurotrauma · 2024Article
- Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.Nature reviews. Neurology · 2024Review
- Functional connectivity associated with attention networks differs among subgroups of fibromyalgia patients: an observational case-control study.Scientific reports · 2024Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Conditioned pain modulation (CPM), a psychophysical paradigm that is commonly used to infer the integrity of endogenous pain-altering systems by observation of the effect of one noxious stimulus on another, has previously identified deficient endogenous analgesia in fibromyalgia (FM) and other chronic pain conditions. The mechanisms underlying this deficiency, be they insufficient inhibition and/or active facilitation, are largely unknown. The present cross-sectional study used a combination of behavioral CPM testing, voxel-based morphometry, and resting state functional connectivity to identify neural correlates of CPM in healthy controls (HC; n = 14) and FM patients (n = 15), and to probe for differences that could explain the pain-facilitative CPM that was observed in our patient sample. Voxel-based morphometry identified a cluster encompassing the periaqueductal gray (PAG) that contained significantly less gray matter volume in FM patients. Higher resting connectivity between this cluster and cortical pain processing regions was associated with more efficient inhibitory CPM in both groups, whereas PAG connectivity with the dorsal pons was associated with greater CPM inhibition only in HC. Greater PAG connectivity to the caudal pons/rostral medulla, which was pain-inhibitory in HC, was associated with pain facilitation in FM patients. PERSPECTIVE: These findings indicate that variation in the strength of the PAG resting functional connectivity can explain some of the normal variability in CPM. In addition, pain-facilitative CPM observed in FM patients likely involves attenuation of pain inhibitory as well as amplification of pain facilitative processes in the central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.