ReviewFree radical biology & medicine2018
Circadian regulation of renal function.
Review in Free radical biology & medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Sodium and Potassium Intake and Cardiovascular Disease in Older People: A Systematic Review.Nutrients · 2020Pooled it
- A randomized vagus nerve stimulation study demonstrates that serum aldosterone levels decrease with age in women, but not in men.Scientific reports · 2023Trial
- Trial
- Physiological glomerular filtration rate and responses to Zeitgeber time and cold stress in C57BL/6 mice.Renal failure · 2026Article
- Practical prediction of 24-hour urinary sodium excretion in young people: a new formula derived from Tanaka and INTERSALT formulas.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Circadian timing of the dystrophin associated complex across the brain and body.Fluids and barriers of the CNS · 2026Review
- Time-of-Day Defines the Risk of Thermally Abused Frying Oil to Renal Injury by Modulating the Diurnal Dynamics of Oxylipins.Exploration (Beijing, China) · 2026Article
- Robustness of urinary extracellular vesicle-derived MiRNA profiles over multiple days and the impact of urine concentration.Scientific reports · 2025Article
- Article
- Disruption of circadian rhythm as a potential pathogenesis of nocturia.Nature reviews. Urology · 2025Review
- Circadian Clock Disruption and Growth of Kidney Cysts in Autosomal Dominant Polycystic Kidney Disease.Journal of the American Society of Nephrology : JASN · 2025Article
- An antagonistic role of clock genes and lima1 in kidney regeneration.Communications biology · 2025Article
- Nocturnal polyuria is common in Parkinson's and is associated with orthostatic hypotension.Clinical parkinsonism & related disorders · 2025Article
- Circadian clocks and their role in kidney and eye diseases across organ systems.Frontiers in physiology · 2025Review
- Circadian Influences on Myocardial Ischemia-Reperfusion Injury and Heart Failure.Circulation research · 2024Review
- Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism.Molecular pharmacology · 2024Review
- The association between circadian syndrome and chronic kidney disease in an aging population: a 4-year follow-up study.Frontiers in endocrinology · 2024Article
- Sex and circadian regulation of metabolic demands in the rat kidney: A modeling analysis.PloS one · 2024Article
- Article
- How kidney clock works: circadian pattern of eGFR based on a population data group.Journal of physiology and biochemistry · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The kidneys regulate many vital functions that require precise control throughout the day. These functions, such as maintaining sodium balance or regulating arterial pressure, rely on an intrinsic clock mechanism that was commonly believed to be controlled by the central nervous system. Mounting evidence in recent years has unveiled previously underappreciated depth of influence by circadian rhythms and clock genes on renal function, at the molecular and physiological level, independent of other external factors. The impact of circadian rhythms in the kidney also affects individuals from a clinical standpoint, as the loss of rhythmic activity or clock gene expression have been documented in various cardiovascular diseases. Fortunately, the prognostic value of examining circadian rhythms may prove useful in determining the progression of a kidney-related disease, and chronotherapy is a clinical intervention that requires consideration of circadian and diurnal rhythms in the kidney. In this review, we discuss evidence of circadian regulation in the kidney from basic and clinical research in order to provide a foundation on which a great deal of future research is needed to expand our understanding of circadian relevant biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.