Evidence map›Paper›PMID 29360499›Full record

ArticleMatrix biology : journal of the International Society for Matrix Biology2018

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow.

Katharina Helene Susek, Eva Korpos, Jula Huppert, Chuan Wu, Irina Savelyeva, Frank Rosenbauer, Carsten Müller-Tidow, Steffen Koschmieder, Lydia Sorokin

Open access · greenAbstract read
In one paragraph

Article in Matrix biology : journal of the International Society for Matrix Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 58 citations in OpenAlex.

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  15. Autophagic Mediators in Bone Marrow Niche Homeostasis.Advances in experimental medicine and biology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Katharina Helene SusekInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany.
Eva KorposInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany.
Jula HuppertInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany.
Chuan WuInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany; Experimental Immunology Branch, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Irina SavelyevaInstitute of Molecular Tumor Biology, University of Muenster, Germany.
Frank RosenbauerCells-in-Motion Cluster of Excellence, University of Muenster, Germany; Institute of Molecular Tumor Biology, University of Muenster, Germany.
Carsten Müller-TidowCells-in-Motion Cluster of Excellence, University of Muenster, Germany; Department of Medicine A-Hematology, Oncology and Pneumology, University Hospital Muenster, Germany; Department of Hematology, Oncology and Rheumatology, University Hospital Heidelberg, Heidelberg Germany.
Steffen KoschmiederCells-in-Motion Cluster of Excellence, University of Muenster, Germany; Department of Medicine A-Hematology, Oncology and Pneumology, University Hospital Muenster, Germany; Department of Hematology, Oncology, Hemostaseology, and Stem Cell Transplantation, Faculty of Medicine, RWTH Aachen University, Aachen, Germany.
Lydia SorokinInstitute of Physiological Chemistry and Pathobiochemistry, University of Muenster, Germany; Cells-in-Motion Cluster of Excellence, University of Muenster, Germany. Electronic address: sorokin@uni-muenster.de.
Institute of Molecular Biology · DEUniversity Hospital Münster · DENational Institutes of Health · US

Funding

The role of Foxo1 for intestinal epithelial cells during mucosal immune responseZIABC011755 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2017 to 2025
$4.1M
T cell regulation for intestinal barrier functionZIABC011801 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WU, CHUAN · 2018 to 2025
$4.1M
Intramural NIH HHS ZIA BC011755
6 · The paper itself

Abstract

Hematopoietic stem and progenitor cell (HSPC) functions are regulated by a specialized microenvironment in the bone marrow - the hematopoietic stem cell niche - of which the extracellular matrix (ECM) is an integral component. We describe here the localization of ECM molecules, in particular the laminin α4, α3 and α5 containing isoforms in the bone marrow. Laminin 421 (composed of laminin α4, β2, γ1 chains) is identified as a major component of the bone marrow ECM, occurring abundantly surrounding venous sinuses and in a specialized reticular fiber network of the intersinusoidal spaces of murine bone marrow (BM) in close association with HSPC. Bone marrow from Lama4

Indexed as

AnimalsBone MarrowCell CycleCell MovementExtracellular MatrixHematopoietic Stem CellsLamininMiceStem Cell NicheLamininBone marrowHematopoietic stem and progenitor cells (HSPC)Laminin

Identifiers

PMID29360499
PMCPMC8108389
OpenAlexW2791707302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.