ArticleScientific data2018
Design and implementation of multi-signal and time-varying neural reconstructions.
Article in Scientific data, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Investigation of the myelin-amyloid interplay in Alzheimer's disease: insights from novel dsCMA imaging in mouse and human brains.Acta neuropathologica communications · 2026Article
- SPCNNet: spiking point cloud neural network for morphological neuron classification.Scientific reports · 2026Article
- Neural networks of the mouse visceromotor cortex.Nature · 2025Article
- Distinct subnetworks of the mouse anterior thalamic nuclei.Nature communications · 2025Article
- Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint.Nature communications · 2024Article
- Online conversion of reconstructed neural morphologies into standardized SWC format.Nature communications · 2023Article
- Local Microtubule and F-Actin Distributions Fully Constrain the Spatial Geometry ofInternational journal of molecular sciences · 2023Article
- The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation inInternational journal of molecular sciences · 2023Article
- The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation inbioRxiv : the preprint server for biology · 2023Article
- Neuron tracing from light microscopy images: automation, deep learning and bench testing.Bioinformatics (Oxford, England) · 2022Review
- Petabyte-Scale Multi-Morphometry of Single Neurons for Whole Brains.Neuroinformatics · 2022Article
- Efficient metadata mining of web-accessible neural morphologies.Progress in biophysics and molecular biology · 2022Article
- A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling.Neuroinformatics · 2022Article
- Quantitative neuronal morphometry by supervised and unsupervised learning.STAR protocols · 2021Article
- Formin 3 directs dendritic architecture via microtubule regulation and is required for somatosensory nociceptive behavior.Development (Cambridge, England) · 2021Article
- An imaging analysis protocol to trace, quantify, and model multi-signal neuron morphology.STAR protocols · 2021Article
- A neuronal blueprint for directional mechanosensation in larval zebrafish.Current biology : CB · 2021Article
- Prediction of Neural Diameter From Morphology to Enable Accurate Simulation.Frontiers in neuroinformatics · 2021Article
- Article
- An open-source framework for neuroscience metadata management applied to digital reconstructions of neuronal morphology.Brain informatics · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Several efficient procedures exist to digitally trace neuronal structure from light microscopy, and mature community resources have emerged to store, share, and analyze these datasets. In contrast, the quantification of intracellular distributions and morphological dynamics is not yet standardized. Current widespread descriptions of neuron morphology are static and inadequate for subcellular characterizations. We introduce a new file format to represent multichannel information as well as an open-source Vaa3D plugin to acquire this type of data. Next we define a novel data structure to capture morphological dynamics, and demonstrate its application to different time-lapse experiments. Importantly, we designed both innovations as judicious extensions of the classic SWC format, thus ensuring full back-compatibility with popular visualization and modeling tools. We then deploy the combined multichannel/time-varying reconstruction system on developing neurons in live Drosophila larvae by digitally tracing fluorescently labeled cytoskeletal components along with overall dendritic morphology as they changed over time. This same design is also suitable for quantifying dendritic calcium dynamics and tracking arbor-wide movement of any subcellular substrate of interest.
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Registered trials
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