ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2019
Coronary vascular age: An alternate means for predicting stress-induced myocardial ischemia in patients with suspected coronary artery disease.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Vascular Age: A narrative review of assessment methods, clinical applications, and future directions.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Association of Cardiovascular Risk Factors and Coronary Calcium Burden with Epicardial Adipose Tissue Volume Obtained from PET-CT Imaging in Oncological Patients.Journal of cardiovascular development and disease · 2024Article
- Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries.Frontiers in cardiovascular medicine · 2023Review
- Diagnostic value of clinical risk scores for predicting normal stress myocardial perfusion imaging in subjects without coronary artery calcium.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Vascular age based on coronary calcium burden and carotid intima media thickness (a comparative study).American journal of nuclear medicine and molecular imaging · 2022Article
- Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Planning the Follow-Up of Patients with Stable Chronic Coronary Artery Disease.Diagnostics (Basel, Switzerland) · 2021Review
- Computed tomography calls out nuclear imaging in its field: It doesn't matter how you are searching but what you are looking for.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- An Update on Coronary Artery Calcium Interpretation at Chest and Cardiac CT.Radiology. Cardiothoracic imaging · 2021Review
- Review of cardiovascular imaging in the Journal of Nuclear Cardiology 2019: Positron emission tomography, computed tomography and magnetic resonance.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Review
- Vascular age for predicting cardiovascular risk: A novel clinical marker or just a mathematical permutation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Hybrid anatomo-functional imaging of coronary artery disease: Beneficial irrespective of its core components.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Review
- Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters.European cardiology · 2019Review
- Sympathetic nervous system in age-related cardiovascular dysfunction: Pathophysiology and therapeutic perspective.The international journal of biochemistry & cell biology · 2019Review
Corrections and comments
- Commented on by
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery calcium (CAC) can be used to estimate vascular age in adults, providing a convenient transformation of CAC from Agatston units into a year's scale. We investigated the role of coronary vascular age in predicting stress-induced myocardial ischemia in subjects with suspected coronary artery disease (CAD).
methodsA total of 717 subjects referred to CAC scoring and
resultsStress-induced ischemia was present in 105 (15%) patients. Mean chronological age, CAC score, and coronary vascular age were higher (all P < .001) in patients with ischemia compared to those without. At incremental analysis, the global Chi square increased from 41.26 to 68.77 (P < .001) when chronological age was added to clinical variables. Including vascular age in the model, the global Chi square further increased from 68.77 to 106.38 (P < .001). Adding chronological age to clinical data, continuous net reclassification improvement (cNRI) was 0.57, while adding vascular age to clinical data and chronological age cNRI was 0.62. At decision curve analysis, the model including vascular age was associated with the highest net benefit compared to the model including only clinical data, to the model including chronological age and clinical data, and to a strategy considering that all patients had ischemia. The model including vascular age also showed the largest reduction in false-positive rate without missing any ischemic patients.
conclusionsIn subjects with suspected CAD, coronary vascular age is strongly associated with stress-induced ischemia. The communication of a given vascular age would have a superior emotive impact improving observance of therapies and healthier lifestyles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.