Evidence map›Paper›PMID 29359176›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2018

Spatiotemporal evolution of venous narrowing in acute MS lesions.

Philipp Eisele, Kristina Szabo, Anne Ebert, Wolfgang Brueck, Michael Platten, Achim Gass

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Philipp EiseleDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
Kristina SzaboDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
Anne EbertDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
Wolfgang BrueckDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
Michael PlattenDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
Achim GassDepartment of Neurology (P.E., K.S., A.E., M.P., A.G.), Universitätsmedizin Mannheim, University of Heidelberg, Mannheim; and Institute for Neuropathology (W.B.), Universitätsmedizin Göttingen, Germany.
University of Mannheim · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs).

methodsWe retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast enhancement. The mean diameter of veins at the time point of contrast enhancement was compared with the mean diameter of veins before and after contrast enhancement.

resultsA total of 40 acute contrast-enhancing lesions with a corresponding intralesional central vein were included in the study. The mean diameter of intralesional veins at the time of contrast enhancement (0.80 ± 0.12 mm) was smaller than that at before (1.16 ± 0.19 mm) and after contrast enhancement (1.07 ± 0.15 mm;

conclusionsOur findings contribute to the increasing database of plaque development and evolution. The smaller diameter of intralesional veins on SWI at the time of blood-brain barrier breakdown may reflect morphologic changes because of perivascular inflammation and/or decreased levels of deoxygenated hemoglobin.

Identifiers

PMID29359176
PMCPMC5773855
OpenAlexW2783218152

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.