Evidence map›Paper›PMID 29359094›Full record

ArticleBiomedical optics express2018

Ultra-high contrast retinal display system for single photoreceptor psychophysics.

Niklas Domdei, Lennart Domdei, Jenny L Reiniger, Michael Linden, Frank G Holz, Austin Roorda, Wolf M Harmening

Abstract read
In one paragraph

Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Optimal Retinal Locus for High-Resolution Vision in Space and Time.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. A paradoxical misperception of relative motion.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. A paradoxical misperception of relative motion.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Niklas DomdeiDepartment of Ophthalmology, University of Bonn, Germany.
Lennart DomdeiDepartment of Ophthalmology, University of Bonn, Germany.
Jenny L ReinigerDepartment of Ophthalmology, University of Bonn, Germany.
Michael LindenDepartment of Ophthalmology, University of Bonn, Germany.
Frank G HolzDepartment of Ophthalmology, University of Bonn, Germany.
Austin RoordaSchool of Optometry and Vision Science Graduate Group, University of California, Berkeley, USA.
Wolf M HarmeningDepartment of Ophthalmology, University of Bonn, Germany.

Funding

Advanced Technology to Study Visual Function on a Cellular ScaleR01EY023591 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI DUNCAN, JACQUE LYNNE, ROORDA, AUSTIN · 2014 to 2023
$11.2M
Interferometric Optophysiology of the Human RetinaU01EY025501 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROORDA, AUSTIN · 2015 to 2019
$3.4M
NEI NIH HHS R01 EY023591NEI NIH HHS U01 EY025501
6 · The paper itself

Abstract

Due to the enormous dynamic range of human photoreceptors in response to light, studying their visual function in the intact retina challenges the stimulation hardware, specifically with regard to the displayable luminance contrast. The adaptive optics scanning laser ophthalmoscope (AOSLO) is an optical platform that focuses light to extremely small retinal extents, approaching the size of single photoreceptor cells. However, the current light modulation techniques produce spurious visible backgrounds which fundamentally limit experimental options. To remove unwanted background light and to improve contrast for high dynamic range visual stimulation in an AOSLO, we cascaded two commercial fiber-coupled acousto-optic modulators (AOMs) and measured their combined optical contrast. By compensating for zero-point differences in the individual AOMs, we demonstrate a multiplicative extinction ratio in the cascade that was in accordance with the extinction ratios of both single AOMs. When latency differences in the AOM response functions were individually corrected, single switch events as short as 50 ns with radiant power contrasts up to 1:10

Indexed as

(110.1080) Active or adaptive optics(230.1040) Acousto-optical devices(330.4300) Vision system - noninvasive assessment(330.5310) Vision - photoreceptors(330.5510) Psychophysics

Identifiers

PMID29359094
PMCPMC5772572

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.