ArticleBiomedical optics express2018
Quantitative observations on cytoskeleton changes of osteocytes at different cell parts using digital holographic microscopy.
Article in Biomedical optics express, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- The Role of Cytoskeleton Revealed by Quartz Crystal Microbalance and Digital Holographic Microscopy.International journal of molecular sciences · 2022Article
- Accurate modulation of photoprinting under stiffness imaging feedback for engineering ECMs with high-fidelity mechanical properties.Microsystems & nanoengineering · 2022Article
- Displacement and strain mapping for osteocytes under fluid shear stress using digital holographic microscopy and digital image correlation.Biomedical optics express · 2021Article
- Quantitative scoring of epithelial and mesenchymal qualities of cancer cells using machine learning and quantitative phase imaging.Journal of biomedical optics · 2020Article
- Investigating Osteocytic Perilacunar/Canalicular Remodeling.Current osteoporosis reports · 2019Review
- An optical study of drug resistance detection in endometrial cancer cells by dynamic and quantitative phase imaging.Journal of biophotonics · 2019Article
- Adaptive frequency filtering based on convolutional neural networks in off-axis digital holographic microscopy.Biomedical optics express · 2019Article
- Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytoskeletons such as F-actin have different distributions in different cell parts and they are the cause of different degrees of cell collapse when the F-actin is disrupted. It is challenging to use conventional methods such as fluorescence microscopy and atomic force microscopy to conduct real-time and three-dimensional observations on the dynamic processes at different cell parts due to the slow measuring speed and the need for live-cell staining. In this study, the morphological variations of different bone cell parts caused by F-actin disruption are dynamically measured by using digital holographic microscopy (DHM). We separately analyze local parameters (cell height and cell width) and global parameters (cell projected area and cell volume) of cells to address variations of specific cell areas and quantify the changing process of the whole cell. We found significant differences in temporal variations of both local and global cell parameters between the cell body and cell process, which is consistent with the qualitative observation by fluorescence staining. Our study not only validates the unique ability of DHM to simultaneously investigate the dynamic process at different cell parts, but also provides sufficient experimental bases for exploring the mechanism for F-actin disruption.
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Registered trials
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